Anatomical balance of the upper airway in Japanese and Caucasian patients with obstructive sleep apnea

2011 Fiscal Year Final Research Report

• Project/Area Number: 21406033
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Social dentistry
• Research Institution: 公益財団法人神経研究所 (2011); Neuropsychiatric Research Institute (2009-2010)
• Principal Investigator: TSUIKI Satoru 公益財団法人神経研究所, 研究部, 研究員 (90376765)
• Co-Investigator(Renkei-kenkyūsha): INOUEY Yuichi 公益財団法人神経研究所, 研究部, センター長 (50213179) ; ISONO Shiroh 千葉大学, 医学研究科, 教授 (80212968) ; MAEDA Keiko 公益財団法人神経研究所, 研究部, 研究員 (30529938)
• Research Collaborator: ALMEIDA Fernanda R. The University of British Columbia, Faculty of Dentistry, Assistant Professor ; LOWE Alan A. The University of British Columbia, Faculty of Dentistry, Professor ; RYAN Frank C. The University of British Columbia, Faculty of Medicine, Professor
• Project Period (FY): 2009 – 2011
• Keywords: 閉塞性睡眠時無呼吸症候群 / 顎顔面形態 / 解剖学的バランス / 舌 / 日本人 / 白人

Research Abstract

Obesity and craniofacial abnormalities are common features of patients with Obstructive Sleep Apnea(OSA). Anatomical balance between the size of the craniofacial rigid enclosure(formed by the dentitions, cervical vertebrae, maxilla, and mandible) and the amount of soft tissue(e. g. tongue) influences the upper airway space and is involved in the pathogenesis of OSA. In this study, we investigated whether this anatomical balance was different between races in OSA people. Blind measurements of tongue cross-sectional area and craniofacial dimensions were performed two dimensionally through lateral cephalograms in 76 Japanese patients with OSA and 74 Caucasian OSA subjects after matching gender(male), age, and apnea hypopnea index. Sagittal tongue size, sagittal maxillomandibular dimensions, and body mass index(BMI) were compared between the groups. While BMI was significantly higher in Caucasians than in Japanese patients, tongue size and maxillomandibular dimensions were not different between the races. These findings suggest that anatomical balance does not differ between Japanese OSA people and Caucasian OSA persons under the same OSA severity. This may partly account for the reason why prevalence of OSA are almost the same between Japanese and Caucasians.

Research Products

• [Journal Article] Difference in dental arch size between obese and non-obese patients with obstructive sleep apnoea (2012)
  • Author(s): Maeda, K., Tsuiki, S., Isono, S., Namba, K., Kobayashi, M., Inoue, Y
  • Journal Title: Journal of Oral Rehabilitation Volume: 39 Pages: 111-117
  • Peer Reviewed
• [Journal Article] Dose-dependent effects of mandibular protrusion on genioglossus activity in sleep apnoea (2011)
  • Author(s): Almeida F. R., Tsuiki, S., Hattori, Y., Takei, Y., Inoue, Y., Lowe, A. A
  • Journal Title: Eur Respir J Volume: 37 Pages: 209-212
  • Peer Reviewed
• [Journal Article] Excessive daytime sleepiness among Japanese public transportation drivers engaged in shift-work (2010)
  • Author(s): Asaoka, S., Namba, K., Tsuiki, S., Komada, Y., Inoue, Y
  • Journal Title: J Occup Environ Med Volume: 52 Pages: 813-818
  • Peer Reviewed
• [Journal Article] Differences in clinical characteristics between two subgroups of obstructive sleep apnea syndrome in the elderly-comparison between cases with elderly and middle age onset- (2010)
  • Author(s): Kobayashi, M., Namba, K., Tsuiki, S., Matsuo, A., Sugiura, T., Inoue, Y
  • Journal Title: Chest Volume: 137 Pages: 1310-1315
  • Peer Reviewed
• [Journal Article] Optimal positive airway pressure predicts oral appliance treatment response to sleep apnoea (2010)
  • Author(s): Tsuiki, S., Kobayashi, M., Namba, K., Oka, Y., Komada, Y., Kagimura, T., Inoue, Y
  • Journal Title: Eur Respir J Volume: 35 Pages: 1098-1105
  • Peer Reviewed
• [Journal Article] Clinical characteristics of familial obstructive sleep apnea syndrome in Japanese (2010)
  • Author(s): Matsuo, A., Inoue, Y., Tsuiki, S., Enomoto, M., Chiba, H
  • Journal Title: Respirology Volume: 15 Pages: 93-98
  • Peer Reviewed
• [Journal Article] Motor vehicle accident(MVA) risk factors for drivers with obstructive sleep apnea syndrome(OSAS) in the Tokyo metropolitan area (2009)
  • Author(s): Komada, Y., Nishida, Y., Namba, K., Tsuiki, S., Abe, T., Inoue, Y
  • Journal Title: Tohoku Journal of Experimental Medicine Volume: 219 Pages: 11-16
  • Peer Reviewed
• [Presentation] Anatomical balance of the upper airway in Japanese and Caucasian patients with obstructive sleep apnea (2011)
  • Author(s): Tsuiki, S., Almeida, F. R
  • Organizer: Worldsleep 2011
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20111016-20
• [Presentation] Possible increase in the severity of obstructive sleep apnea in patients with orthodontic premolar extractions (2011)
  • Author(s): Fukuda, T., et al
  • Organizer: 20^<th> Anniversary Meeting of the American Academy of Dental Sleep Medicine
  • Place of Presentation: Minneapolis, Minnesota, USA
  • Year and Date: 20110610-12
• [Presentation] Optimal positive airway pressure predicts oral appliance treatment response to sleep apnoea (2010)
  • Author(s): Tsuiki, S., et al
  • Organizer: European Respiratory Society
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20100918-22
• [Presentation] How mandibular advancement modulates genioglossus muscle activity in obstructive sleep apnoea (2010)
  • Author(s): Almeida F. R., et al
  • Organizer: European Respiratory Society
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20100918-20
• [Presentation] Posttreatment objective evaluation of oral appliances for obstructive sleep apnoea (2010)
  • Author(s): Tsuiki, S., et al
  • Organizer: 20th Congress of the European Sleep Research Society
  • Place of Presentation: Lisbon, Portugal
  • Year and Date: 20100914-18
• [Presentation] Does dental arch size affect obstructive sleep apnea (2010)
  • Author(s): Maeda, K., et al
  • Organizer: International Association for Dental Research General Session
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20100714-17
• [Presentation] Dose-dependent effects of mandibular protrusion on genioglossal activity in obstructive sleep apnoea (2010)
  • Author(s): Almeida F. R., et al
  • Organizer: American Thoracic Society 2010 Louisiana International Conference
  • Place of Presentation: Louisiana
  • Year and Date: 20100519-24
• [Presentation] A comparison of oral appliance efficacy with CPAP in patients with positional-dependent obstructive sleep apnea (2009)
  • Author(s): Tsuiki, S, et al
  • Organizer: The 6th Congress of Asian Sleep Research Society, The 34th Annual Meeting of Japanese Society of Sleep Research and The 16th Annual Meeting of Japanese Society for Chronobiology Joint Congress
  • Place of Presentation: Osaka, Japan
  • Year and Date: 20091024-27
• [Presentation] Can we predict oral appliance treatment response to obstructive sleep apnea based on optimal positive airway pressure (2009)
  • Author(s): Tsuiki, S, et al
  • Organizer: American Academy of Dental Sleep Medicine 18th Annual Meeting
  • Place of Presentation: Seattle, USA
  • Year and Date: 20090605-07
• [Presentation] Tongue size and dental arch changes in obese obstructive sleep apnea patients (2009)
  • Author(s): Maeda, K., et al
  • Organizer: American Academy of Dental Sleep Medicine 18th Annual Meeting
  • Place of Presentation: Seattle, USA.
  • Year and Date: 20090605-07
• [Book] ライフ・サイエンス、睡眠呼吸障害Update2011 (2011)
  • Author(s): 對木悟, 他
  • Total Pages: 188-194
• [Book] 睡眠時無呼吸症候群-改訂第2版- (2009)
  • Author(s): 對木悟
  • Total Pages: 152-156
  • Publisher: 克誠堂出版
• [Book] 睡眠検査学の基礎と臨床 (2009)
  • Author(s): 對木悟
  • Total Pages: 176-179
  • Publisher: 新興医学出版社
• [Book] 睡眠学 (2009)
  • Author(s): 對木悟
  • Total Pages: 637-639
  • Publisher: 朝倉書店
• [Remarks] Best Oral Presentation賞Tsuiki, S, Kobayashi M, Namba K, Oka Y, Inoue Can we predict oral appliance treatment response to obstructive sleep apnea based on optimal positive airway pressure? 2009年アメリカ睡眠歯科学会, June 6th, 2009, Seattle, Washington
• [Patent(Industrial Property Rights)] 舌位置制御装置 (2010)
  • Inventor(s): 對木悟、南野脩
  • Industrial Property Rights Holder: 對木悟、南野脩
  • Industrial Property Number: 特許、第4445565号
  • Acquisition Date: 2010-01-22
• [Patent(Industrial Property Rights)] Tongue position controller (2009)
  • Inventor(s): TSUIKI Satoru, MINAMINO Osamu
  • Industrial Property Rights Holder: TSUIKI Satoru, MINAMINO Osamu
  • Industrial Property Number: 特許、PCT/JP2009/051427
  • Filing Date: 2009-01-29
  • Overseas