2011 Fiscal Year Final Research Report
Comprehensive analysis of the structural information of disorder proteins using computers
| Project/Area Number |
21500289
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAKAMURA Shugo 東京大学, 大学院・農学生命科学研究科, 准教授 (90272442)
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| Project Period (FY) |
2009 – 2011
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| Keywords | コンピュータシミュレーション / ディスオーダー蛋白質 |
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| Research Abstract |
I have applied protein structure prediction method and molecular dynamics simulation to amino acid sequences of various intrinsically disordered regions/proteins(IDRs/IDPs). I found that these amino acid sequences include structural information as the same degree of loop regions of ordered proteins and that tertiary structures of some IDPs after complex formation are even predictable without information of partner proteins.
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