2011 Fiscal Year Final Research Report
Molecular basis of neuron-specific, activity-dependent regulation of the plasticity-related gene Arc
| Project/Area Number |
21500301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKUNO Hiroyuki 東京大学, 大学院・医学系研究科, 助教 (80272417)
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| Co-Investigator(Renkei-kenkyūsha) |
BITO Haruhiko 東京大学, 大学院・医学系研究科, 准教授 (00291964)
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| Project Period (FY) |
2009 – 2011
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| Keywords | シナプス / 脳・神経 / ゲノム / 転写調節 / Arc |
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| Research Abstract |
The neuronal immediate-early gene Arc, which plays critical roles in long-term synaptic plasticity and long-term memory formation, is dynamically regulated by neuronal activities in the brain. Through this study, we have determined several genomic regulatory elements in the Arc promoter, and have identified transcription factors that contribute to activity-dependent expression. We further uncovered a novel mechanism by which Arc protein is localized and thus regulates glutamate receptor trafficking at synapses.
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Research Products
(22 results)
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[Presentation] Enhanced synaptic accumulation of activity-driven Arc protein during sensory deprivation in the mouse visual cortex2011
Author(s)
Okuno, H ; Fujii, H ; Kawashima, T ; Nonaka, M ; Yagishita-Kyo, N ; Ishii, Y ; Takemoto-Kimura, S ; Chowdhury, S ; Worley, PF ; Bito, H.
Organizer
第40回北米神経科学学会年会(Neuroscience 2010)
Place of Presentation
San Diegoコンベンションセンター(米国)
Year and Date
2011-11-17
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