2011 Fiscal Year Final Research Report
Analysis of the growth factor-mediated affective behavior and the correlation with adult neurogenesis.
| Project/Area Number |
21500306
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyushu University |
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Principal Investigator |
UDO Hiroshi 九州大学, 大学院・理学研究院, 助教 (70363322)
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| Project Period (FY) |
2009 – 2011
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| Keywords | マウス / 脳 / 成長因子 / 神経新生 / 情動 / うつ / 気分障害 |
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| Research Abstract |
We have characterized the effect of growth factors on affective behaviors and adult neurogenesis using mouse models. We showed that VEGF has antidepressant-and anxiolytic-like effects as well as the ability to enhance adult neurogenesis, which were found to involve monoaminergic modulation. In contrast, although bFGF tended to enhance memory, it did not influence affective behaviors as well as the level of adult neurogenesis.
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