2011 Fiscal Year Final Research Report
The mechanisms for generation of rhythmic activities in the interneuronal networks
| Project/Area Number |
21500317
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Tamagawa University |
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Principal Investigator |
TSUKAMOTO Yoko (FUJIWARA yoko) 玉川大学, 脳科学研究所, 嘱託研究員 (90209130)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 海馬 / リズム / 介在細胞 / 神経回路 / 生理学 / 脳・神経 / GABA / ギャップ結合 |
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| Research Abstract |
The aim of our research is to elucidate the mechanisms for generation of rhythmic activities in the brain, such as EEG and epilepsy. In this study, we analyzed rhythmic neuronal synchronization induced by strong electrical stimulation in acute slice preparations of rat hippocampus and cerebral cortices, using whole-cell patch-clamp technique. We found that a network of fast-spiking interneurons alone can drive the electrically induced rhythmic activity(prototypic afterdischarge) in the hippocampal CA1 area, entorhinal cortex and neocortex.
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[Journal Article] Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons2010
Author(s)
Fujiwara-Tsukamoto, Y., Isomura, Y., Imanishi, M., Ninomiya, T., Tsukada, M., Yanagawa, Y., Fukai, T., Takada, M.
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Journal Title
J. Neurosci
Volume: 30(41)
Pages: 13679-89
DOI
Peer Reviewed
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