Mechanism for determination of synaptic critical period in brains

2011 Fiscal Year Final Research Report

• Project/Area Number: 21500323
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: MIYATA Seiji 京都工芸繊維大学, 工芸科学研究科, 准教授 (30243124)
• Project Period (FY): 2009 – 2011
• Keywords: プロテオグリカン / 臨界期 / 脳 / 可塑性 / シナプス

Research Abstract

Mechanism for determination of synaptic critical period in brains Chondroitin sulfate proteoglycans(CSPGs) are main components of extracellular matrix in the mammalian brains and possibly concerned with synaptic plasticity. The present study reveals that tPA-plasminogen system is responsible for synaptic plasticity in the hypothalamic vasopressinergic neurons in vivo. Moreover, it is shown that CSPG-degrading enzyme Chase increases the expression of a synaptic plasticity marker GAP-43 in cultured hippocampal neurons in vitro. Thus, the present results demonstrates that CSPGs are crucial role in synaptic plasticity by regulating their expression.

Research Products

• [Journal Article] A new method for visualization of endothelial cells and extra vascular leakage in adult mouse brain using fluoresce in isothiocyanate (2011)
  • Author(s): Miyata S, Morita S.
  • Journal Title: Journal of Neuroscience Methods Volume: 202 Pages: 9-16
  • URL: http://www.journals.elsevier.com/journal-of-neuroscience-methods/
  • Peer Reviewed
• [Journal Article] Mixture of cis-3-hexanol and trans-2-hexanol attenuates behavioral and stress responses induced by 2, 5-dihydro-2, 4, 5-trimethylthiazoline and electric foot shock stress in rats (2011)
  • Author(s): Nikaido, Y., Miyata, S., Nakashima, T.
  • Journal Title: Physiology & Behavior Volume: 103 Pages: 547-556
  • URL: http://www.journals.elsevier.com/p
  • Peer Reviewed
• [Journal Article] Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus (2011)
  • Author(s): Taniguchi, Y., Inoue, N., Morita, S., Nikaido, Y., Nakashima, T., Nagai, N., Okada, K., Matsuo, O., Miyata, S.
  • Journal Title: Cell and Tissue Research Volume: 343 Pages: 303-317
  • URL: http://www.springer.com/biomed/human+genetics/journal/41
  • Peer Reviewed
• [Journal Article] Activity-dependent remodeling of chondroitin sulfate proteoglycan extra cellular matrix in the hypothalamo-neurohypophysial system (2010)
  • Author(s): Morita, S., Oohira, A., Miyata, S.
  • Journal Title: Neuroscience Volume: 166 Pages: 1068-1082
  • URL: http://ees.elsevier.com/nsc/
  • Peer Reviewed
• [Journal Article] Tissue plasminogen activator and plasminogen are critical for osmotic homeostasis by regulating vasopressin secretion (2010)
  • Author(s): Imamura, Y., Morita, S., Nakatani, N., Okada, K., Ueshima, S., Matsuo, O., Miyata, S.
  • Journal Title: Journal of Neuroscience Research Volume: 88 Pages: 1995-2006
  • URL: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4547
  • Peer Reviewed
• [Journal Article] OBCAM, an immunoglobulin super family cell adhesion molecule, regulates morphology and proliferation of cerebral astrocytes (2010)
  • Author(s): Sugimoto, C., Maekawa, S., Miyata, S.
  • Journal Title: Journal of Neurochemistry Volume: 112 Pages: 818-828
  • URL: http://www.blackwellpublishing.com/jnc_enhanced/
  • Peer Reviewed
• [Journal Article] Functional difference of receptor-type protein tyrosine phosphatase zeta/beta is forms in neurogenesis of hippocampal neurons (2009)
  • Author(s): Asai, H., Yokoyama, S., Morita, S., Maeda, N., Miyata, S.
  • Journal Title: Neuroscience Volume: 164 Pages: 1020-30
  • URL: http://ees.elsevier.com/nsc/
  • Peer Reviewed
• [Journal Article] IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neuros (2009)
  • Author(s): Hashimoto, T., Maekawa, S., Miyata, S.
  • Journal Title: Cell Biochemistry and Function Volume: 27 Pages: 496498
  • URL: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-084
  • Peer Reviewed
• [Journal Article] Expression of chondroitin sulfate proteoglycan in barrel fields of rodents (2009)
  • Author(s): Nakamura, M., Nakano, K., Morita, S., Nakashima, T., Oohira, A., Miyata, S.
  • Journal Title: Brain Research Volume: 1252 Pages: 117-129
  • URL: http://ees.elsevier.com/bres/
  • Peer Reviewed
• [Journal Article] European Journal of Neuroscience
  • Author(s): Morita S, Ukai, S., Miyata S.
  • Volume: (in press)
  • URL: http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1460-9568
  • Peer Reviewed
• [Journal Article] Different vascular permeability between the sensory and secretory circumventricular organs of adult mouse brain
  • Author(s): Morita S, Miyata S.
  • Journal Title: Cell and Tissue Research Volume: (in press)
  • URL: http://www.springer.com/biomed/human+genetics/journal/441
  • Peer Reviewed
• [Journal Article] Over expression of IgLON cell adhesion molecules changes proliferation and cell size of cortical astrocytes
  • Author(s): Sugimoto C, Morita S, Miyata S.
  • Journal Title: Cell Biochemistry and Function Volume: (in press)
  • URL: http://onlinelibrary.wiley.com/journal/10.1002/)1099-0844
  • Peer Reviewed
• [Journal Article] Effect of pleiotrophin on glutamate-induced neurotoxicity in cultured hippocampal neurons
  • Author(s): Asai H, Morita S, Miyata S.
  • Journal Title: Cell Biochemistry and Function Volume: 29 Pages: 660-665
  • URL: http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-084
  • Peer Reviewed
• [Presentation] Continuous angiogenesis in the circumventricular organs of the adult brain (2011)
  • Author(s): Morita S, Miyata S.
  • Organizer: Neurogenesis 2011
  • Place of Presentation: Kobe
  • Year and Date: 20110000
• [Presentation] 浸透圧刺激による脳室周囲器官の血管構築変化 (2011)
  • Author(s): 森田晶子・蓬莱敦・鵜飼真璃・奥田洋明・辰巳晃子・和中明生・宮田清司
  • Organizer: 第87回日本解剖学会近畿支部学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20110000
• [Presentation] 脳室周囲器官の血管新生は血液情報感知とペプチド分泌に関与する (2011)
  • Author(s): 森田晶子・宮田清司
  • Organizer: 第38回日本神経内分泌学会学術集会(内分泌学ウィーク2011)
  • Place of Presentation: 東京
  • Year and Date: 20110000
• [Presentation] 末梢血液情報の変化による脳室周囲器官の血管再構築 (2011)
  • Author(s): 蓬莱敦・森田晶子・宮田清司
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 20110000
• [Presentation] 脳室周囲器官における神経ならびに血管新生の環境因子 (2011)
  • Author(s): 鵜飼真璃・飯森菜月・森田晶子・宮田清司
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 20110000
• [Presentation] 成体脳室周囲器官における血管再構築機序の解析 (2011)
  • Author(s): 森田晶子・萬成哲也・宮田清司
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 20110000
• [Presentation] 脳室周囲器官では持続的に血管新生が起きている (2011)
  • Author(s): 森田晶子・中島敏博・宮田清司
  • Organizer: 第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 20110000
• [Presentation] 免疫グロブリンスーパーファミリー接着因子OBCAMによるアストロサイトの増殖制御 (2010)
  • Author(s): 宮田清司・杉本千明・森田晶子
  • Organizer: 第86回日本解剖学会近畿支部学術集会
  • Place of Presentation: 泉佐野市
  • Year and Date: 20100000
• [Presentation] 脳室周囲器官における血管系のDynamics (2010)
  • Author(s): 森田晶子・宮田清司
  • Organizer: 第86回日本解剖学会近畿支部学術集会
  • Place of Presentation: 泉佐野市
  • Year and Date: 20100000
• [Presentation] 中枢神経細胞におけるtPAならびにPlasminogenの小胞における局在 (2010)
  • Author(s): 宮田清司・井上直子・森田晶子・蓬莱敦
  • Organizer: Neuro2010第33回日本神経科学大会,第53回日本神経化学会大会,第20回日本神経回路学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 20100000
• [Presentation] 視床下部におけるtPAならびにplasminogenの局在解析 (2010)
  • Author(s): 谷口由樹・森田晶子・井上直子・宮田清司
  • Organizer: Neuro2010(第33回日本神経科学大会,第53回日本神経化学会大会,第20回日本神経回路学会大会合同大会)
  • Place of Presentation: 神戸市
  • Year and Date: 20100000
• [Presentation] 脳室周囲器官におけるneurogenesisとangiogenesis (2010)
  • Author(s): 森田晶子・宮田清司
  • Organizer: Neuro2010(第33回日本神経科学大会,第53回日本神経化学会大会,第20回日本神経回路学会大会合同大会)
  • Place of Presentation: 神戸市
  • Year and Date: 20100000
• [Presentation] Expression of chondroitin sulfate proteoglycans in osmoregulatory brain regions (2010)
  • Author(s): Morita S, Miyata S.
  • Organizer: Official Satellite Symposium of the 14th International Congress of Endocrinology
  • Place of Presentation: Kyoto
  • Year and Date: 20100000
• [Presentation] 下垂体後葉神経系におけるコンドロイチン硫酸プロテオグリカンと構造的可塑性 (2009)
  • Author(s): 森田晶子・宮田清司
  • Organizer: 第85回日本解剖学会近畿支部学術集会
  • Place of Presentation: 橿原市
  • Year and Date: 20090000
• [Presentation] 視床下部下垂体後葉系におけるコンドロイチン硫酸プロテオグリカンの神経活動依存的発現変化 (2009)
  • Author(s): 森田晶子・大平敦彦・宮田清司
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 古屋市
  • Year and Date: 20090000
• [Presentation] tPA-plasminシステムによるバソプレッシン分泌調節に関する研究 (2009)
  • Author(s): 宮田清司、今村友樹、井上直子、岡田清隆、松尾理
  • Organizer: 第31回日本止血血栓学会
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Presentation] 神経培養系を用いたPerineuronal netsの機能解析 (2009)
  • Author(s): 中野恵子、宮田清司
  • Organizer: 第31回日本神経科学会
  • Place of Presentation: 東京
  • Year and Date: 20090000
• [Presentation] tPA-plasminシステムによるバソプレッシン分泌調節に関する研究 (2009)
  • Author(s): 今村友樹、井上直子、松尾理、宮田清司
  • Organizer: 第31回日本神経科学会
  • Place of Presentation: 東京
  • Year and Date: 20090000
• [Presentation] tPA-plasminシステムによる細胞外マトリクス分解とバソプレッシン神経の構造的可塑性 (2009)
  • Author(s): 宮田清司、今村友樹、松尾理
  • Organizer: 第30回日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 20090000
• [Presentation] 神経細胞における受容体型タンパクチロシンフォスファターゼβアイソフォームの機能 (2009)
  • Author(s): 横山彰太、前田信明、宮田清司
  • Organizer: 第30回日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 20090000
• [Presentation] Perineuronal netsの神経保護作用と可塑性に関する研究 (2009)
  • Author(s): 中村充、中野恵子、宮田清司
  • Organizer: 第30回日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 20090000
• [Presentation] IgLON接着因子の海馬神経シナプス形成における役割 (2009)
  • Author(s): 橋本隆、前川昌平、宮田清司
  • Organizer: 第30回日本神経科学会
  • Place of Presentation: 横浜
  • Year and Date: 20090000
• [Presentation] 中枢神経系にける神経細胞接着因子OBCAMとKilonの機能解析 (2009)
  • Author(s): 橋本隆、山田真弓、前川昌平、宮田清司
  • Organizer: 第112回日本解剖学会
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Presentation] バソプレッシン分泌におけるtPA-plasminシステムの関与 (2009)
  • Author(s): 宮田清司、中谷佳弘、斉藤大輔、岡田清孝、松尾理
  • Organizer: 第112回日本解剖学会
  • Place of Presentation: 大阪
  • Year and Date: 20090000
• [Remarks]
  • URL: http://www.cis.kit.ac.jp/～smiyata/top.htm