2011 Fiscal Year Final Research Report
Research on the structural plasticity and pathogenesis of depressive disorders
| Project/Area Number |
21500328
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Nerve anatomy/Neuropathology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
JINNO Shozo 九州大学, 大学院・医学研究院, 教授 (10325524)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 神経回路網 / 構造的可塑性 / ステレオロジー / うつ病 |
|---|
| Research Abstract |
We carried out the neuroscience research on the morphological plasticity of neurons and glial cells constituting neuronal network, and obtained the following outcomes.(1) Adult neurogenesis in the dentate gyrus declined more severely in the ventral hippocampus than in the dorsal hippocampus.(2) Numerical densities of astrocytes increased in the stratum lacunosum-moleculare in the ventral hippocampus but not in the dorsal hippocampus with aging.(3) In the axotomy model, astrocytic, but not microglial, reaction may primarily mediate some anti-apoptotic effects through synaptic stripping.
|
-
-
-
-
-
-
-
-
[Journal Article] Cortical GABAergic Neurons : Stretching it Remarks, Main Conclusions and Discussion2010
Author(s)
Clancy B, Defelipe J, Espinosa A, Fairen A, Jinno S, Kanold P, Luhmann HJ, Rockland KS, Tamamaki N, Yan XX.
-
Journal Title
Front Neuroanat
Volume: 4(7)
Pages: 1-18
-
-
-
-
-
-
-
-
-
-
-
-
-
