2012 Fiscal Year Final Research Report
Regulatory mechanism for spine morphogenesis by a small G-protein Rheb
| Project/Area Number |
21500332
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
SUGIURA Hiroko 公益財団法人東京都医学総合研究所, 基盤技術研究センター, 基盤技術研究職員 (40162870)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Hidekazu 大阪大学, 医学系研究科, 准教授 (70273638)
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| Co-Investigator(Renkei-kenkyūsha) |
KATSURABAYASHI Shutaro 福岡大学, 薬学部, 助教 (50435145)
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| Project Period (FY) |
2009 – 2012
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| Keywords | スパイン / Rheb |
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| Research Abstract |
An activity-regulated small G-protein Rheb is activated in tuberous sclerosis, which is accompanied with dendritic spine dysmorphogenesis. We have investigated the underlying mechanism and have clarified that mitochondria is increased in dendrites of tuberous sclerosis neurons and that impaired spinogenesis in tuberous sclerosis is caused by an increase in RBP levels, not due to mTORC1 activation. These findings may lead to development of a new treatment for tuberous sclerosis associated with epilepsy, mental retardation or autism.
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