2011 Fiscal Year Final Research Report
Establishing glioma stem cell library together with its ontogenic and phenotypical analysis of glioma
| Project/Area Number |
21500335
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Gunma University |
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Principal Investigator |
YOKOO Hideaki 群馬大学, 大学院・医学系研究科, 准教授 (40282389)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAZATO Yoichi 群馬大学, 大学院・医学系研究科, 教授 (10106908)
SASAKI Atsushi 埼玉医科大学, 医学部, 教授 (80225862)
ISHIUCHI Shogo 琉球大学, 医学部, 教授 (10312878)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 脳腫瘍 / グリオーマ / 免疫組織化学 / 腫瘍幹細胞 / 遺伝子改変ラット / EGFR / CD133 / NG2 |
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| Research Abstract |
Antibodies to human CD133/prominin1, rat CD133/prominin1, human NG2/CSPG4 were developed. Glioma stem cell library was developed by culturing human glioma cell under stem cell condition. Genetic analysis of chromosome 19q13.42 in embryonal tumors with multilayered rosettes, and IDH1 in oligodendroglial tumors was carried out. S100β-verbB transgenic rat prone to glioma was analyzed.
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