2011 Fiscal Year Final Research Report
Insulin resistance and protective role for antioxidative peptide in ischemic white matter damages
| Project/Area Number |
21500338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Juntendo University |
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Principal Investigator |
URABE Takao 順天堂大学, 医学部, 教授 (60291663)
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| Co-Investigator(Kenkyū-buntansha) |
SIMOSAWA Tatsuo 東京大学, 医学部, 講師 (90231365)
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| Project Period (FY) |
2009 – 2011
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| Keywords | アドレノメデュリン / 抗酸化ペプチド / 慢性脳低灌流 / 虚血性脳白質障害 / 酸化ストレス / インスリン抵抗性 / 認知障害 / 脳保護作用 |
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| Research Abstract |
This study showed that adrenomedullin(AM), which is reported as antioxidative peptide, has an important protective function against oxidative stress through the cyclic AMP. protein kinase A pathway. We indicated that downregulation of AM results in high levels of reactive oxygen species(ROS) and enhanced progression of infarction area after transient focal ischemia in mice. In chronic cerebral hypoperfusion of AM deficient mice, oxidative stress and inflammatory response enhanced progression of white matter damages. It suggest that augmentation or activation for AM may be suppressed oxdative stress and shown the brain protective effect.
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