2011 Fiscal Year Final Research Report
Research for scientific evidences on diagnostic epilepsy pathology
| Project/Area Number |
21500342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | 財団法人東京都医学総合研究所 (2011)
Tokyo Metropolitan Organization for Medical Research (2009-2010) |
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Principal Investigator |
ARAI Nobutaka 財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 参事研究員 (10167984)
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| Project Period (FY) |
2009 – 2011
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| Keywords | てんかん / 脳外科治療 / 外科病理診断 / アストロサイト / 組織鉄 / 外傷性てんかん |
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| Research Abstract |
The specific aim of this study is focused on disclosing of pathological changes, if any, causing intractable epilepsy. Both of abnormal deposit of iron granules in the astrocytes and abnormal immunohistochemial expression of glutamate transporter of glia type were observed in normal-looking area around organic lesions, taken from epileptogenic cortices by neurosurgical procedures. Those findings strongly suggest a possibility that dysfunction of the astrocytes causes epilepsy.
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