2011 Fiscal Year Final Research Report
Search for the epigenetic transcription factor related to fear extinction
| Project/Area Number |
21500344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Chiba University |
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Principal Investigator |
SHIMIZU Eiji 千葉大学, 大学院・医学研究院, 教授 (00292699)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 恐怖消去 / 感覚ゲート機構 / NMDA受容体 / DNAメチル化 / 調整誘発電位P50 |
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| Research Abstract |
To investigate what the change of DNA methylation in the brain alter behavior, mice were fed with methyl donor deficient diet in their 3wk to 6wk age. Difference in expression of NMDA receptor NR2B subunit in the hippocampus was considered as a cause of the behavioral change after the diet. In human, our results suggested that auditory evoked potential P50 differed according to the cognition of the properties (potentially dangerous or safe) of the perceived signal.
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Research Products
(10 results)
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[Journal Article] Effects of aripiprazole on MK-801-induced prepulse inhibition deficits and mitogen-activated protein kinase signal transduction pathway2010
Author(s)
Ishii D, Matsuzawa D, Kanahara N , Matsuda S, Sutoh C, Ohtsuka H, Nakazawa K, Kohno M, Hashimoto K, Iyo M, Shimizu E
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Journal Title
Neuroscience Letters
Volume: 471(1)
Pages: 53-57
DOI
Peer Reviewed
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[Journal Article] Impaired P50 suppression in fear extinction in obsessive-compulsive disorder2009
Author(s)
Nanbu M, Kurayama T, Nakazawa K, Matsuzawa D , Komiya Z, Haraguchi T, Ogura H, Hashimoto T, Yoshida S, Iyo M, Shimizu E
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Journal Title
Prog Neuropsychopharmacol Biol Psychiatry
Volume: 34(2)
Pages: 317-22
DOI
Peer Reviewed
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