2011 Fiscal Year Final Research Report
Investigation of the regulatory mechanism of neuronal insulin receptor signaling in pursuit of the improvement of insulin resistance.
| Project/Area Number |
21500350
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NEMOTO Takayuki 宮崎大学, 医学部, 助教 (90506833)
WADA Akihiko 宮崎大学, 医学部, 教授 (30131949)
MURAKAMI Manabu 宮崎大学, 医学部, 教授 (80302090)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞内情報伝達 / インスリン受容体シグナル / 神経変性疾患 / 認知症 / 神経保護 / 神経障害 |
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| Research Abstract |
Dysregulated insulin receptor signaling(insulin resistance) may be involved in dementia and neurodegenerative disease(e. g. Alzheimer's disease), thus insulin receptor signaling being the major molecular targets of neuroprotective drugs. In the present study, we have demonstrated that the insulin receptor signaling was up-and down-modulated by several therapeutic drugs and bioactive agents(e. g. nicotine, crucmin, docosahexaenoic acid, immunosuppressants and alchol) via multiple intracellular mechanisms.
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[Journal Article] Transcriptional up-regulation of cell surface Na_V1. 7 sodium channels by insulin-like growth factor-1 via inhibition of glycogen synthase kinase-3βin adrenal chromaffin cells : enhancement of ^22Na^+ influx,^45Ca<2+> influx and catecholamine secretion2011
Author(s)
Yanagita T, Satoh S, Uezono Y, Matsuo K, Nemoto T, Maruta T, Yoshikawa N, Iwakiri T, Minami K, Murakami M
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Journal Title
Neuropharmacology
Volume: 61
Pages: 1265-1274
Peer Reviewed
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[Journal Article] Chronic lithium treatment up-regulates cell surface Na_V1. 7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells : enhancement of Na^+ influx, Ca^<2+> influx and catecholamine secretion after lithium withdrawal2009
Author(s)
Yanagita T, Maruta T, Nemoto T, Uezono Y, Matsuo K, Satoh S, Yoshikawa N, Kanai T, Kobayashi H, Wada A
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Journal Title
Neuropharmacology
Volume: 57
Pages: 311-321
Peer Reviewed
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