2011 Fiscal Year Final Research Report
Redox regulation of calmodulin kinase I in neurons
| Project/Area Number |
21500354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Showa Pharmaceutical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIYA Yukihiro 昭和薬科大学, 薬学部, 助教 (30455406)
NOZAKI Naohito 神奈川歯科大学, 歯学部, 講師 (70222198)
KAMBE Toshie 昭和薬科大学, 薬学部, 講師 (80276625)
MIYAMOTO Yoshiaki 昭和薬科大学, 薬学部, 助教 (20449101)
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| Co-Investigator(Renkei-kenkyūsha) |
NOZAKI Naohito 神奈川歯科大学, 歯学部, 講師 (70222198)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞内情報伝達 |
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| Research Abstract |
Many intracellular signaling events are regulated by Ca^<2+> signals in neurons. It has also been reported that these events are accompanied by generation of reactive oxygen species. Here, we show that oxidation and Ca^<2+> signals are mutual regulated in cells. We propose that oxidation stress might regulate neuronal function via cross-talk with Ca^<2+> signals.
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[Journal Article] Two naturally occurring terpenes, dehydrocostuslactone and costunolide decrease intracellular GSH content and inhibit STAT3 activation2011
Author(s)
Butturini E., Cavalieri E., Carcereri de Prati, A., Darra E., Rigo A., Shoji K., MurayN., Yamazaki H., Watanabe Y., Suzuki H. Mariotto S
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Journal Title
PLoS ONE
Volume: 6(5)
Pages: 20174
URL
Peer Reviewed
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[Presentation] 月桂樹由来テルペンのSTAT3活性化と抗腫瘍効果2009
Author(s)
Elena Butturini, Elisabetta Cavalieri, Elena Darra, Alessandra Carcereri de Prati, Sofia Mariotto, Kazuo Shoji, Yasuo Watanabe, Hisanori Suzuki
Organizer
第9回日本NO学会
Place of Presentation
静岡
Year and Date
20090508-09
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