2011 Fiscal Year Final Research Report
Asymmetric endocytosis across the growth cone that controls axon guidance
| Project/Area Number |
21500361
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KAMIGUCHI Hiroyuki 独立行政法人理化学研究所, 神経成長機構研究チーム, チームリーダー (10233933)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 軸索 / 成長円錐 / ガイダンス / エンドサイト-シス / エキソサイトーシス / カルシウム / カルシニューリン / サイクリン依存性キナーゼ |
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| Research Abstract |
Neuronal circuits are formed by axons that have elongated and reached their targets. The tip of each axon, called the growth cone, explores extracellular guidance cues and can turn in the appropriate direction. In this project, we found that repulsive cues cause asymmetric endocytosis across the growth cone via cytosolic Ca^<2+> signals and that this asymmetric endocytosis is both necessary and sufficient for repulsive guidance. We also showed that a localized imbalance between endocytosis and exocytosis drives growth cone turning.
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