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2011 Fiscal Year Final Research Report

Obsessive compulsive disorder-related striosome circuits in the striatum

Research Project

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Project/Area Number 21500362
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

AOSAKI Toshihiko  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (70221033)

Project Period (FY) 2009 – 2011
Research Abstract

The striatal striosome compartment is considered one of the critical stations related to obsessive compulsive disorder. Medium spiny projection neurons in the striosomes but not in the matrix have mu-opioid receptors whose physiological roles have not fully examined. We found that prior blockade of muscarinic receptors augmented the suppressive effect of the mu-opioid receptor agonist DAMGO on the inhibitory postsynaptic currents. This phenomenon suggests the notion that the cessation of tonic action potential discharges of cholinergic interneurons in the striatum(the pause response of the tonically active cholinergic neurons of the striatum) during behavioral learning induces disinhibition of neuronal activities of the striosomal medium spiny neurons which are believed to encode motivational information.

  • Research Products

    (30 results)

All 2012 2011 2010 2009 Other

All Journal Article (11 results) (of which Peer Reviewed: 7 results) Presentation (18 results) Remarks (1 results)

  • [Journal Article] Imbalanced suppression of excitatory and inhibitory synaptic transmission onto mouse striatal projection neurons during start of anesthesia induction with sevoflurane in vitro2012

    • Author(s)
      Ose, Y., Miura, M., Inoue, R., Andou, N., Aosaki, T., Nishimura, K
    • Journal Title

      European Journal of Neuroscience

      Volume: 35 Pages: 1396-1405

    • DOI

      doi:10.1111/j.1460-9568.2012.08065.x

    • Peer Reviewed
  • [Journal Article] The suppressive effect ofμ-opioid receptors on GABAergic IPSC is modulated by alteration of PKC activity via muscarinic receptors in striosomes of the mouse striatum2012

    • Author(s)
      Inoue, R., Aosaki, T., Miura, M
    • Journal Title

      Neuro Report

      Volume: 23(3) Pages: 184-188

    • DOI

      DOI:10.1097/WNR.0b013e32834faab0

    • Peer Reviewed
  • [Journal Article] 和文総説:「パーキンソン病におけるコリン作動性ニューロン」2012

    • Author(s)
      三浦正巳、井上律子、青崎敏彦
    • Journal Title

      Clinical Neuroscience

      Volume: 30 Pages: 697-699

    • URL

      https://www.chugaiigaku.jp/modules/shop/index.php?main_page=product_info & cPath=3_73 & products_id=1260

  • [Journal Article] Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum2011

    • Author(s)
      Masuda, M., Miura, M., Imanishi, M., Saino-Saito, S., Inoue, R., Takada, M., Kobayashi, K., Aosaki, T
    • Journal Title

      European Journal of Neuroscience

      Volume: 34 Pages: 1355-1367

    • DOI

      doi:10.1111/j.1460-9568.2011.07873.x

    • Peer Reviewed
  • [Journal Article] Usp46, encoding a ubiquitin specific peptidase, is a quantitative trait gene underlying "behavioral despair" in mice2010

    • Author(s)
      Ebihara, S., Tomida, S., Mamiya, T., Sakamaki, H., Miura, M., Aosaki, T., Masuda, M., Niwa, M., Kameyama, T., Kobayashi, J., Iwaki, Y., Imai, S., Ishikawa, A., Abe, K., Yoshimura, T., Nabeshima, T
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 8(2) Pages: 114-119

    • DOI

      DOI:10.1111/j.1479-8425.2010.00435.x

    • Peer Reviewed
  • [Journal Article] Activin Bi-directionally Controls the Fate of Fear Memory2010

    • Author(s)
      Ageta, H., Ikegami, S., Miura, M., Masuda, M., Migishima, R., Hino, T., Takashima, N., Murayama, A., Sugino, H., Setou, M., Kida, S., Yokoyama, M., Yoshihisa Hasegawa, Y., Tsuchida, K., Aosaki, T., Inokuchi, K
    • Journal Title

      Learning and Memory

      Volume: 17 Pages: 176-185

    • DOI

      doi:10.1101/lm.16659010

    • Peer Reviewed
  • [Journal Article] Acetylcholine-dopamine balance hypothesis in the striatum : an update2010

    • Author(s)
      Aosaki, T., Miura, M., Suzuki, T., Nishimura, K. and Masuda, M
    • Journal Title

      Geriatrics and Gerontology International

      Volume: 10 Pages: 148-157

    • DOI

      doi:10.1111/j.1447-0594.2010.00588.x

  • [Journal Article] 中枢神経系におけるドーパミン受容体のはたらき2009

    • Author(s)
      三浦正巳、増田正雄、青崎敏彦
    • Journal Title

      生体の科学

      Volume: 60(5) Pages: 4123-413

    • URL

      http://ej.islib.jp/ejournal/2425100895.html?

  • [Journal Article] Identification of Usp46, encoding a ubiquitin specific peptidase, as a quantitative trait gene regulating mouse immobile behavior in the tail suspension test and the forced swimming test2009

    • Author(s)
      Tomida, S., Mamiya, T., Sakamaki, H., Miura, M., Aosaki, T., Masuda, M., Niwa, M., Kameyama, T., Kobayashi, J., Iwaki, Y., Imai, S., Ishikawa, A., Abe, K., Yoshimura, T., Nabeshima, T., Ebihara, S
    • Journal Title

      Nature Genetics

      Volume: 41(6) Pages: 688-695

    • DOI

      doi:10.1038/ng.344

    • Peer Reviewed
  • [Journal Article] Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice2009

    • Author(s)
      Sato, T., Miura, M., Yamada, M. Yoshida, T., Wood, J. D., Yazawa, I., Masuda, M., Suzuki, T., Shin, R-M., Yau, H-J., Liu, F-C., Shimohata, T., Onodera, O., Ross, C. A., Katsuki, M., Takahashi, H., Kano, M., Aosaki, T., Tsuji, S
    • Journal Title

      Human Molecular Genetics

      Volume: 18(4) Pages: 723-736

    • DOI

      doi:10.1093/hmg/ddn403

    • Peer Reviewed
  • [Journal Article] 線条体におけるアセチリコリンとドーパミンの生理的相互作用2009

    • Author(s)
      青崎敏彦、三浦正巳、増田正雄
    • Journal Title

      Brain and Nerve

      Volume: 61(4) Pages: 373-380

    • URL

      http://ej.islib.jp/ejournal/1416100461.html?

  • [Presentation] ニコチン受容体の脱感作は線条体コリン作動性ニューロンへのGABA入力を調節する2012

    • Author(s)
      三浦正巳、井上律子、青崎敏彦
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本文化会館
    • Year and Date
      20120329-31
  • [Presentation] Postnatal development of intrinsic tyrosine hydroxylase mRNA-expressing neurons in the striatum2012

    • Author(s)
      Toshihiko Aosaki, Masao Masuda, Masami Miura, Ritusko Inoue
    • Organizer
      第85回日本薬理学会年会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2012-03-28
  • [Presentation] Suppressive effect on GABAergic IPSC viaμ-opioid receptor is modulated by endogenous acetylcholine in the mouse striatum2011

    • Author(s)
      Ritsuko Inoue, Masami Miura, Toshihiko Aosaki
    • Organizer
      The Society for Neuroscience 41st Annual Meeting
    • Place of Presentation
      Washington, D. C., USA
    • Year and Date
      20111112-16
  • [Presentation] 「μオピオイド受容体作動薬と内在性アセチルコリンがマウス線条体のGABA作動性抑制電流に与える影響」Neuro20112011

    • Author(s)
      井上律子、三浦正巳、青崎敏彦
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      20110914-17
  • [Presentation] 「線条体チロシン水酸化酵素mRNA陽性細胞の分類と生後発達」JBAGS2011

    • Author(s)
      増田正雄、三浦正巳、今西美知子、齋野・斉藤幸子、井上律子、高田昌彦、小林和人、青崎敏彦
    • Organizer
      第26回日本大脳基底核研究会
    • Place of Presentation
      神奈川県・箱根町・パレスホテル箱根
    • Year and Date
      20110702-03
  • [Presentation] マウス線条体におけるμオピオイド受容体の効果に内在性アセチルコリンが及ぼす影響2011

    • Author(s)
      井上律子、三浦正巳、青崎敏彦
    • Organizer
      第34回日本基礎老化学会大会
    • Place of Presentation
      東京
    • Year and Date
      20110615-17
  • [Presentation] アセチルコリンはマウス線条体の抑制性電流に対するμオピオイド受容体の抑制効果を減弱する2011

    • Author(s)
      井上律子、三浦正巳、青崎敏彦
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Year and Date
      20110328-30
  • [Presentation] 「吸入麻酔薬セボフルレンのマウス線条体ニューロンに対する作用」Neuro20102010

    • Author(s)
      大瀬善之、三浦正巳、井上律子、青崎敏彦、西村欣也
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      20100902-04
  • [Presentation] マウス線条体チロシンヒドロキシラーゼmRNA陽性細胞の生理学的性質2010

    • Author(s)
      青崎敏彦、増田正雄、三浦正巳、今西美智子、井上律子、齋野・齋藤幸子、高田昌彦、小林和人
    • Organizer
      日本基礎老化学会第33回大会
    • Place of Presentation
      名古屋
    • Year and Date
      20100617-18
  • [Presentation] 線条体におけるアセチリコリンとドーパミンの生理的相互作用とシナプス可塑性2010

    • Author(s)
      青崎敏彦
    • Organizer
      平成22年度生理学研究所研究会
    • Place of Presentation
      岡崎
    • Year and Date
      20100610-11
  • [Presentation] Roles of cholinergic interneurons in inter-compartmental communication and synaptic plasticity in the striatum2010

    • Author(s)
      Aosaki, T., Miura, M
    • Organizer
      The Journal of Physiological Sciences
    • Place of Presentation
      盛岡
    • Year and Date
      20100000
  • [Presentation] 東京農工大学大学院修士課程講義2010

    • Author(s)
      青崎敏彦
    • Organizer
      環境老年学特論II:パーキンソン病の発症メカニズム
    • Place of Presentation
      東京
    • Year and Date
      2010-07-13
  • [Presentation] 自治医大時代2010

    • Author(s)
      青崎敏彦
    • Organizer
      木村實先生定年退職記念講演会「視覚、大脳基底核研究から異分野統合的脳研究へ」
    • Place of Presentation
      京都
    • Year and Date
      2010-05-22
  • [Presentation] 動物のメンタリティーを測定する2009

    • Author(s)
      青崎敏彦
    • Organizer
      第105・106回老年学公開講座
    • Year and Date
      20091008-1112
  • [Presentation] 線条体コリン作動性インターニューロンのGABA性入力の調節機構2009

    • Author(s)
      三浦正巳、増田正雄、青崎敏彦
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      20090916-18
  • [Presentation] Roles of cholinergic interneurons in inter-compartmental communication and synaptic plasticity in the striatum2009

    • Author(s)
      Aosaki, T
    • Organizer
      Satellite Symposiumof the 32nd Annual Meeting of the Japan Neuroscience Society The Basal Ganglia in Health and Disease
    • Place of Presentation
      シンポジウム
    • Year and Date
      20090914-15
  • [Presentation] GABA性の抑制低下とうつ病様行動異常2009

    • Author(s)
      三浦正巳、富田滋、間宮隆吉、酒巻大岳、増田正雄、丹羽美苗、亀山勉、小林淳哉、井脇有香、今井早希、石川明、安部訓也、吉村崇、鍋島俊隆、海老原史樹文、青崎敏彦
    • Organizer
      日本基礎老化学会第32回大会
    • Place of Presentation
      横浜
    • Year and Date
      20090618-20
  • [Presentation] パーキンソン病のしくみと治療の最前線2009

    • Author(s)
      青崎敏彦
    • Organizer
      当事者と介護者のための特別講演会,主催わかな会
    • Place of Presentation
      川崎市麻生区
    • Year and Date
      2009-04-18
  • [Remarks]

    • URL

      http://www.tmig.or.jp/

URL: 

Published: 2013-07-31  

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