2011 Fiscal Year Final Research Report
Molecular mechanisms of microglial process extension and migration
| Project/Area Number |
21500363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
OHSAWA Keiko 独立行政法人国立精神・神経医療研究センター, 神経研究所・代謝研究部, 室長 (40392435)
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| Co-Investigator(Renkei-kenkyūsha) |
SANAGI Tomomi 独立行政法人国立精神・神経医療研究センター, 神経研究所代謝研究部, 研究員 (00527012)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ミクログリア / 突起伸長 / 細胞移動 / 細胞外ヌクレオチド / アデノシン |
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| Research Abstract |
Microglia are the primary immune surveillance cells in the brain. Microglial process extension and migration toward injured sites in the brain is triggered by the stimulation of the purinergic receptor P2Y12 by extracellular ATP. In this study, we found that adenosine A3 receptor(A3R) co-operated with P2Y12 to promote microglial process extension and migration. A3R mRNA was clearly observed in microglia sorted from normal adult brains. From these results we concluded that adenosine signaling might play an important role in mediating the change in microglial motility from the resting state to the activated state after brain injury or disease.
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Research Products
(13 results)
