Functions of ascending, descending and recurrent inputs to the lateral geniculate nucleus of thalamus

2011 Fiscal Year Final Research Report

• Project/Area Number: 21500369
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Osaka University
• Principal Investigator: SATO Hiromichi 大阪大学, 大学院・医学系研究科, 教授 (50154092)
• Project Period (FY): 2009 – 2011
• Keywords: 視覚 / 外側膝状体 / 網膜神経節細胞 / 一次視覚野

Research Abstract

To clarify the mechanisms underlying the receptive field(RF) properties of the lateral geniculte nucleus(LGN), we examined the RF properties of retinal ganglion cells(RGCs), neurons in the LGN and visual cortex, and functional interactions among them in the anesthetized and paralyzed cats. The classical receptive field(CRF) of RGC and LGN neurons are elliptical in shape with suppressive extra-classical RE surround(ECRF), which produce tuning properties to the stimulus orientation and spatial frequency. These results suggest that, in the early visual system, the feedforward mechanism makes the basic tuning properties, and the feedback mechanisms enhance the tuning properties via non-linear operation of ECRF

Research Products

• [Journal Article] Cholinergic modulation of response gain in the primary visual cortex of the macaque (2012)
  • Author(s): Soma, S., Shimegi, S., Osaki, H. and Sato, H
  • Journal Title: J. Neurophysiol Volume: 107 Pages: 283-291
  • DOI: doi:10.1152/jn.00330.2011
• [Journal Article] Surround suppression by high spatial frequency stimulus in the cat primary visual cortex : A possible basis for scale-invariant processing of image-frequency (2011)
  • Author(s): Osaki, H., Naito, T., Sadakane, O., Okamoto, M and Sato, H
  • Journal Title: Eur. J. Neurosci Volume: 33 Pages: 923-932
  • DOI: DOI:10.1111/j.1460-9568.2010.07572.x
• [Journal Article] Direction anisotropy of human motion perception depends on stimulus speed (2010)
  • Author(s): Naito, T., Sato, H. and Osaka, N
  • Journal Title: Vision Res Volume: 50(18) Pages: 1862-1866
• [Journal Article] Temporal properties of spatial frequency tuning of surround suppression in the primary visual cortex and the lateral geniculate nucleus of the cat (2010)
  • Author(s): Ishikawa, A., Shimegi, S., Kida, H. and Sato, H
  • Journal Title: Eur. J. Neurosci Volume: 31 Pages: 2086-2100
• [Journal Article] Surround suppression sharpens orientation tuning on the cat primary visual cortex (2009)
  • Author(s): Okamoto, M., Naito, T., Sadakane, O., Osaki, H. and Sato, H
  • Journal Title: Eur. J. Neurosci Volume: 29 Pages: 1035-1046
• [Presentation] ラット一次視覚野におけるコリン作動性ゲイン調節. Gain control by acethylcholine of the rat primary visual cortex (2012)
  • Author(s): 相馬祥吾、七五三木聡、佐藤宏道
  • Organizer: 第89回日本生理学会大会、ポスター
  • Place of Presentation: 松本
  • Year and Date: 20120000
• [Presentation] 初期視覚系における広域視野情報の統合機序(How is wide-field information integrated in the early visual system?) (2012)
  • Author(s): 七五三木聡、木村晃大、原真一郎、相馬祥吾、佐藤宏道
  • Organizer: 第89回日本生理学会大会、国際交流委員会/ KOJACHシンポジウム(Korea-Japan-China Joint Symposium)「初期視覚系ニューロンの受容野特性のダイナミクス(Recent advances in physiological functions and mechanisms of early visual system)」
  • Place of Presentation: 松本
  • Year and Date: 2012-03-30
• [Presentation] ネコ初期視覚系における受容野周囲抑制と方位選択性 (2012)
  • Author(s): 内藤智之、佐藤宏道
  • Organizer: 平成23年度京都大学霊長類研究所共同利用研究会「行動特性を支配するゲノム基盤と脳機能の解明」
  • Place of Presentation: 京都大学霊長類研究所
  • Year and Date: 2012-03-03
• [Presentation] Spatial-frequency and stimulus size dependent response modulation sharpens orientation tuning generated by elliptical receptive field in the cat lateral geniculate nucleus (2011)
  • Author(s): Suematsu, N., Naito, T. and Sato, H
  • Organizer: (poster) Society for Neuroscience
  • Place of Presentation: Washington DC
  • Year and Date: 2011-11-13
• [Presentation] ネコ外側膝状体における方位選択性を形成する楕円形線形受容野と非線形応答修飾 (2011)
  • Author(s): 末松尚史、内藤智之、佐藤宏道
  • Organizer: 第34回日本神経科学大会、ポスター
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2011-09-17
• [Presentation] ネコ外側膝状体中継細胞における空間周波数選択性の形成に及ぼす興奮性メカニズムとGABA抑制の役割 (2011)
  • Author(s): 木村晃大、七五三木聡、原真一郎、岡本正博、佐藤宏道
  • Organizer: 第34回日本神経科学大会、ポスター
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2011-09-15
• [Presentation] Properties and mechanisms of orientation tuning of the cat lateral geniculate nucleus (2011)
  • Author(s): Sato, H., Naito, T., Osaki, H., Suematsu, N., Sadakane, O., Okamoto, M. and Shimegi, S
  • Organizer: IBRO International Congress of Neuroscience
  • Place of Presentation: Florence, Italy
  • Year and Date: 2011-07-17
• [Presentation] A comparison of receptive field properties between functionally connected neurons in the lateral gniculate nucleus and the perigeniculate nucleus of the cat (2011)
  • Author(s): Osaki, H., Naito, T., Soma, S. and Sato, H
  • Organizer: IBRO International Congress of Neuroscience
  • Place of Presentation: Florence, Italy
  • Year and Date: 2011-07-15
• [Presentation] Response gain control by acethylcholine of the macaque monkey primary visual cortex (2010)
  • Author(s): Soma, S., Shimegi, S., Osaki, H., Kimura, A, Naito, T., Hara, S.-I. and Sato, H
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-16
• [Presentation] Role of GABAa and GABAb receptors on the spatial frequency tuning of relay cells in the dorsal lateral geniculate nucleus of the cat (2010)
  • Author(s): Kimura, A., Shimegi, S., Hara, S.-I., Okamoto, M., and Sato, H
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: San Diego
  • Year and Date: 2010-11-14