Analysis of dynamic interaction between dopamine receptors and calcium channels located on the synaptic terminals in the basal forebrain

2011 Fiscal Year Final Research Report

• Project/Area Number: 21500374
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: MOMIYAMA Toshihiko 東京慈恵会医科大学, 医学部, 教授 (20230055)
• Project Period (FY): 2009 – 2011
• Keywords: 前脳基底核 / シナプス / ドーパミン受容体 / カルシウムチャネル / パッチクランプ / カーボンナノチューブ

Research Abstract

The present electrophysiological study has clarified a developmental increase in dopamine D1-like receptor-mediated inhibition of glutamatergic transmission onto cholinergic neurons in the rat basal forebrain through adenylyl cyclase and P/Q-type calcium channel regulation.
The present electrochemical study, introducing a new biosensor material, carbon nanotube, has succeeded in the detection of physiologically released dopamine as a redox current in brain slice preparation. Furthermore, the present study has established a method for simultaneous recordings of dopamine release and membrane potential, thereby clarifying that activation of D2-like receptors reduces dopamine release by hyperpolarizing the membrane of dopaminergic neurons.

Research Products

• [Journal Article] Thromboxane receptor activation enhances striatal dopamine release, leading to suppression of GABAergic transmission and enhanced sugar intake (2011)
  • Author(s): Mitsumori T., Furuyashihki T., Momiyama T., Nishi A., Shuto T., Hayakawa T., Ushikubi F., Kitaoka S., Aoki T., Inoue H., Matsuoka T. & Narumiya S.
  • Journal Title: European Journal of Neuroscience Volume: 34 Pages: 594-604
  • DOI: DOI:10.1111/j.1460-9568.2011.07774.x.
  • Peer Reviewed
• [Journal Article] Developmental increase in D1-like dopamine receptor-mediated inhibition of glutamatergic transmission through P/Q-type channel regulation in the basal forebrain of rats (2010)
  • Author(s): Momiyama T.
  • Journal Title: European Journal of Neuroscience Volume: 32 Pages: 579-590
  • DOI: DOI:10.1111/j.1460-9568.2010.07306.x
  • Peer Reviewed
• [Journal Article] The Pdlns(3, 4) P2-phosphatase INPP4A is a suppressor of excitotoxic neuronal death (2010)
  • Author(s): Sasaki J., Kofuji S., Itoh R., Momiyama T., Takayama K., Murakami H., Chida S., Tsuya Y., Takasuga S., Eguchi S., Asanuma K., Horie Y., Miura K., Davis M., Mitchell C., Yamazaki M., Hirai H., Takenawa T., Suzuki A. & Sasaki T.
  • Journal Title: Nature Volume: 465 Pages: 497-501
  • DOI: doi:10.1038/nature09023
  • Peer Reviewed
• [Journal Article] Growth factors induce striatal neurogenesis and generate region-specific functional mature neurons after ischemia (2010)
  • Author(s): Yoshikawa G., Momiyama T., Oya S., Takai K., Tanaka J., Higashiyama S., Saito N., Kirino T. & Kawahara N.
  • Journal Title: Journal of Neurosurgery Volume: 113 Pages: 835-850
  • DOI: DOI:10.3171/2010.2.JNS09989.
  • Peer Reviewed
• [Journal Article] Prostaglandin E receptor EP1 enhances GABA-mediated inhibition of dopaminergic neurons in the substantia nigra pars compacta and regulates dopamine revel in the dorsal striatum (2009)
  • Author(s): Tanaka Y., Furuyashiki T., Momiyama T., Namba H., Mizoguchi A., Mitsumori T., Kayahara T., Shichi H., Kimura K., Matsuoka T., Nawa H. & Narumiya S.
  • Journal Title: European Journal of Neuroscience Volume: 30 Pages: 2338-2346
  • DOI: DOI:10.1111/j.1460-9568.2009.07021.x
  • Peer Reviewed
• [Presentation] 笹岡俊邦ドーパミン受容体ノックアウトマウスにおける行動および線条体抑制性シナプス伝達の解析 (2012)
  • Author(s): 籾山俊彦、佐藤朝子、勝木元也、笹岡俊邦
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本
  • Year and Date: 2012-03-29
• [Presentation] ラット中脳ドーパミン性ニューロンからのドーパミン遊離とニューロン活動の同時記録 (2012)
  • Author(s): 籾山俊彦
  • Organizer: 第85回日本薬理学会年会シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2012-03-16
• [Presentation] ドーパミンD1およびD2受容体ノックアウトマウスにおける行動および線条体GABA性シナプス伝達の解析 (2011)
  • Author(s): 籾山俊彦、佐藤朝子、勝木元也、笹岡俊邦
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-17
• [Presentation] Motor activity and GABAergic synaptic transmission of dopamine D1 and D2 receptor knock-out mice (2011)
  • Author(s): Momiyama T., Sato A., Katsuki M. & Sasaoka T.
  • Organizer: 8^<th> International Congress of Neuroscience
  • Place of Presentation: Florence, Italy
  • Year and Date: 2011-07-17
• [Presentation] カーボンナノチューブ電極を用いたドーパミン性ニューロン細胞体からのドーパミン遊離検出 (2010)
  • Author(s): 籾山俊彦
  • Organizer: 第33回日本神経科学大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] Motor activity and GABAergic synaptic transmission of dopamine receptor knock-out mice (2010)
  • Author(s): Momiyama T., Sato A., Katsuki M. & Sasaoka T.
  • Organizer: 7^<th> FENS Forum of European Neuroscience
  • Place of Presentation: Amsterdam, The Netherland
  • Year and Date: 2010-07-04
• [Presentation] 前脳基底核アセチルコリン性ニューロンへの興奮性シナプス伝達に対するドーパミンD1型受容体を介する抑制の細胞内情報伝達系 (2009)
  • Author(s): 籾山俊彦
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-17
• [Presentation] GABAergic synaptic transmission in the striatum of dopamine receptor knock-out mice (2009)
  • Author(s): Momiyama T., Sato A., Katsuki M. & Sasaoka T.
  • Organizer: XXXVI International Congress of Physiological Sciences(IUPS2009)
  • Place of Presentation: Kyoto
  • Year and Date: 2009-07-29
• [Book] 「中枢神経興奮薬」リッピンコットシリーズイラストレイテッド薬理学 (2010)
  • Author(s): 籾山俊彦
  • Total Pages: 675
  • Publisher: 丸善
• [Book] Developmental changes in the calcium channel and D1-like receptors involved in the glutamatergic transmission onto rat basal forebrain cholinergic neurons (2009)
  • Author(s): Momiyama T.
  • Total Pages: 299-305