2011 Fiscal Year Final Research Report
Pathophysiology of basal ganglia disorders analyzed by neuronal recording from mouse models in awake state
| Project/Area Number |
21500378
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
CHIKEN Satomi 生理学研究所, 統合生理研究系, 助教 (30396262)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 姿勢 / 運動制御 |
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| Research Abstract |
Dystonia is a neurological disorder characterized by sustained or repetitive involuntary muscle contractions and abnormal postures. To understand the pathophysiology of dystonia, neurophysiological analyses were performed on two kinds of mouse models for dystonia in awake state. Abnormal spontaneous neuronal firings of the internal segment of the globus pallidus neurons(GPi) were observed in the mouse models. In addition, motor cortical stimulation evoked abnormal responses of the GPi neurons in the mouse models for dystonia. The results suggest that abnormal firings and cortically evoked response patterns of GPi neurons are participate in the abnormal motor control in dystonia.
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