2011 Fiscal Year Final Research Report
Cellular mechanisms underlying synaptic plasticity in the thalamostriatal inputs
| Project/Area Number |
21500380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
MIURA Masami 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 専門副部長 (40291091)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生理学 / 脳・神経 / 大脳基底核 / 姿勢・運動 |
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| Research Abstract |
The balance between acetylcholine and dopamine in the striatum conducts the synaptic plasticity in the striatum. Intrinsic striatal cholinergic interneurons receive excitatory thalamostriatal inputs and then change levels of endogenous acetylcholine. In theμ-opioid receptor(MOR)-rich striosomes, activation of PKC via M1 muscarinic receptors attenuated the suppressive effect of MOR on the GABAergic inputs to the projection neurons. These results suggest that reduction of endogenous acetylcholine can increase the excitability of the striatal neural circuits by facilitating the disinhibition of projection neurons.
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[Journal Article] Imbalanced suppression of excitatory and inhibitory synaptic transmission onto mouse striatal projection neurons during induction of anesthesia with sevoflurane in vitro2012
Author(s)
Ose, Y, Miura, M, Inoue, R, Andou, N, Aosaki, T and Nishimura, K
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Journal Title
Eur J Neurosci
Volume: 35
Pages: 1396-1405
DOI
Peer Reviewed
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[Journal Article] Activin plays a key role in the maintenance of long-term memory and late-LTP2010
Author(s)
Ageta H, Ikegami S, Miura M, Masuda M, Migishima R, Hino T, Takashima N, Murayama A, Sugino H, Setou M, Kida S, Yokoyama M, Hasegawa Y, Tsuchida K, Aosaki T, Inokuchi K
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Journal Title
Learn Mem
Volume: 17
Pages: 176-185
Peer Reviewed
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[Journal Article] Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests2009
Author(s)
Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T. and Ebihara S
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Journal Title
Nat Genet
Volume: 41
Pages: 688-695
Peer Reviewed
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[Journal Article] Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice2009
Author(s)
Sato T, Miura M, Yamada M, Yoshida T, Wood J D, Yazawa I, Masuda M, Suzuki T, Shin R M, Yau H J, Liu F C, Shimohata T, Onodera O, Ross C A, Katsuki M, Takahashi H, Kano M, Aosaki T and Tsuji S
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Journal Title
Hum Mol Genet
Volume: 18
Pages: 723-736
Peer Reviewed
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