2011 Fiscal Year Final Research Report
Identification of tyrosine-sulfated proteins essential for sperm-egg interaction
| Project/Area Number |
21500385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Hokkaido University |
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Principal Investigator |
SASAKI Nobuya 北海道大学, 大学院・獣医学研究科, 准教授 (20302614)
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| Project Period (FY) |
2009 – 2011
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| Keywords | チロシン硫酸化 / 精巣-卵子融合 |
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| Research Abstract |
Tyrosine (Tyr) sulfation is a common posttranslational modification of secreted proteins or membrane-bound proteins that is implicated in numerous physiological and pathological processes. Interestingly, the Tpst2mutant shows severe hypothyroidism and male infertility due to the abnormality of sperm transport and capacitation and /or fertilization. These results suggest that the unknown testis specific protein(s) are preferentially sulfated by TPST2. In this study, I tried to identify Tyr-sulfated-protein(s) essential for sperm-egg adhesion.
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