2011 Fiscal Year Final Research Report
Mechanism of the inhibition of cancer cell growth using low voltage electric pulses
| Project/Area Number |
21500402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Okayama University of Science (2010-2011)
Tohoku University (2009) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | エレクトロポレーション / アポトーシス / 低電圧電気パルス / カスパーゼ / 膜透過性 |
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| Research Abstract |
We previously reported that cancer cell apoptosis was induced through electroporation(membrane pore formation) with the application of low voltage electric pulses(LVEPs). In this study, we reported about the apoptosis mechanism of cancer cells that LVEPs impose cell stress and induce apoptosis through caspases activation of both cell death receptor and mitochondrial pathways following intrcellular Ca++elevation. A series of our studies suggest that LVEPs which might be mild damage to the patients could take place of high voltage electrochemtherapy which is studied as a new anti-cancer therapy.
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