2012 Fiscal Year Final Research Report
Development andApplication of Methodology of Magnetic Resonance Measurement of Hyperpolarized Noble Gas Contributable to Physiological Diagnosis.
| Project/Area Number |
21500408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka University |
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Principal Investigator |
KIMURA Atsuomi 大阪大学, 大学院・医学系研究科, 准教授 (70303972)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 超偏極希ガス / 磁気共鳴イメージング(MRI) / 肺機能 / 脳機能 / 慢性閉塞性肺疾患(COPD) |
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| Research Abstract |
The continuous-flow type apparatus for producing hyperpolarized xenon (HP Xe) which can improve the sensitivity by ca. 20,000 times has been successfully developed in the present study. Adopting HP Xe MRI to the lungimaging, we developed the methodology to simultaneously perform the pulmonary functional imaging and the relaxation rate measurement in the brain of HP Xe and investigated the relationship between the two functions of the mouse models of COPD. As a result, the regional abnormalities of the pulmonary funation could be visualized, and the T1i-1was increased compared to that of the healthy mouse. A negative correlation between the T1i-1and the % gas-exchange in the lung was observed.
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