2011 Fiscal Year Final Research Report
Structural evaluation of stratum corneum investigated by electron spin resonance imaging
| Project/Area Number |
21500410
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Hirosaki University (2010-2011)
Fukushima Medical University (2009) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIRATA Hitoshi 北海道大学, 大学院・情報科学研究科, 教授 (60250958)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生体情報 / 計測 |
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| Research Abstract |
Electron spin resonance (ESR) in conjunction with a slow-tumbling simulation was utilized for defining various stratum corneum (SC) lipid structures. The α-terpineol enhanced about three times permeation of the single chain 5-DSA than that of the control. We also studied psoriasis vulgaris SC (pv-SC). We found that the pv-SC is less ordering of the structure than that of the control SC, indicating abnormal architecture of the pv-sc.
A 9 GHz ESR imager that is capable of the imaging surface area of thin materials has been built. More importantly, the TE111 cavity does not require inserting the sample into the cavity and placing samples into ESR tubes. In addition, the components of the 9 GHz imager and imaging data processing are developed.
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[Book] Maibach Eds, Springer-Verlag2009
Author(s)
K. Nakagawa
Total Pages
725-733
Publisher
Structure of stratum corneum lipid studied by electron paramagnetic resonance, Chapter 70, Textbook of Aging Skin, Miranda A. Farage, Kenneth W. Miller and Howard I
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