2011 Fiscal Year Final Research Report
Research on analysis of histological images using dark-field illumination
| Project/Area Number |
21500413
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Shibaura Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Masayuki 横浜市立大学, 附属市民総合医療センター, 教授 (00092073)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 医用・生体画像 / 診断支援 / 病理組織 |
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| Research Abstract |
Dark field image was applied for the analysis of histological images. As a result, a method to extract nuclear positions and fibers from the images of hepatic histological sections stained with silver and HE(hematoxylin-eosin) was realized. The accuracy for extracting nuclear positions, nuclear contours and cell membranes in HE-stained hepatic histological images was also improved. So, dark field images were useful in the analysis of histological images. A diagnosis support system was developed. The system has functions to automatically extract nuclear positions, nuclear contours and cell membranes. The user can easily correct wrong results using a graphical user interface, and can calculate various useful features.
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