2011 Fiscal Year Final Research Report
What should we do to integrate total systems of cell sorters into one chip?
| Project/Area Number |
21500415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Toyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMORO Tomomi 東洋大学, 理工学部, 教授 (60230819)
MIZUKI Toru 東洋大学, 理工学部, 助教 (80408997)
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| Co-Investigator(Renkei-kenkyūsha) |
KASHIWAGI Kunihiro 東洋大学, 工学部, 名誉教授 (30058094)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生体・情報計測 / オンチップセルソーター / SOI / SOQ |
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| Research Abstract |
By combining the electrophoresis method and the conventional Coulter method, we previously proposed the Electrophoretic Coulter Method(ECM)- a technique that enables simultaneous analysis of the size and ζvalues of individual specimens. In this study, we validate ECM in ζmeasurement of biological cells by a conventional Dynamic Light Scattering(DLS) to apply ECM to the field of clinical medicine. We use sheep's red blood cells(RBCs) as biological cells. The ζof RBC is varied by adsorption of Immunogloblin G(IgG) to RBC. We are able to obtain the difference between ζs of RBCs and those of RBCs-IgG by using ECM. In addition, we demonstrate thatζs obtained using ECM show a good agreement with those obtained by the conventional DLS and our ECM can distinguish biological cells using the difference ofζs. Furthermore, we propose that SOI(Silicon On Insulator) wafers or SOQ(Silicon On Quartz) wafers should be utilized as platforms for integration of ECM systems combined with electric detectors or optical detectors and sorting systems, and we characterize fundamental characteristics of SOI wafers and SOQ wafers in detail.
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[Journal Article] Dispersion of single-walled carbon nanotubes modified with poly-l-tyrosine in water2011
Author(s)
M. Kojima, T. Chiba, J. Niiishima, H. Higashi, F. Fukuda, Y. Nakajima, S. Kurosu, T. Hanajiri, K. Ishii, T. Maekawa, A. Inoue
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Journal Title
Nano Scale Research Letters
Volume: 6
Pages: 128-134
Peer Reviewed
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[Remarks] (国際シンポジウム(審査なし))(1) Y. Nakajima, K. Ogata, H. Miyazawa, N. Takahashi, A. Aki, T. Hanajiri, and T. Sugano,"Devolopment of high-resolution bio-nano analytical systems embedded in SOQ warers", 9^<th> Int. Symp. on Bioscience and Nanotechnology(2011), p. 15(10 Dec. 2011, Toyo Univ., Japan)
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[Remarks] (2) K. Ogata, N. Takahashi, A. Aki, Y. Nakajima, and T. Hanajiri, "The Validation of Zeta Potential of Biological Cells Estimated by Electrophoresis Coulter Method", 9^<th> Int. Symp. on Bioscience and Nanotechnology(2011), p. 38(10 Dec. 2011, Toyo Univ., Japan)
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[Remarks] (3) Q. Zhao, H. Miyazawa, Y. Nakajima, T. Hanajiri, and T. Sugano, "Characterization of defects near SOI/BOX interface of SOI wafere", 9^<th> Int. Symp. on Bio-science and Nanotechnology(2011) p. 39(10 Dec. 2011, Toyo Univ., Japan).
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[Remarks] (4) Y. Watanabe, Y. Nakajima, T. Toyabe, T. Hanajiri, and T. Sugano, "Influence of local stress on traps in SOI layers of SOI wafers", 8^<th> Int. Symp. on Bioscience and Nanotechnology., p. 64(2010)(17-18 Nov. 2010, Toyo Univ., Japan)
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[Remarks] (5) K. Ogata, N. Takahashi, A. Aki, Y. Nakajima, and T. Hanajiri, "Extraction of Zeta Potential on Channel Walls for Electrophoretic Coulter Method Accuracy Improvement", 8^<th> Int. Symp. on Bioscience and Nanotechnology(2010), p. 65(17-18 Nov. 2010, Toyo Univ., Japan)
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[Remarks] (6) H. Miyazawa, Y. Nakajima, T. Sugano, and T. Hanajiri, "Characterization of distribution of traps in SOI layers of SIMOX wafers", 8^<th> Int. Symp. on Bioscience and Nanotechnology(2010) p. 66(17-18 Dec. 2010, Toyo Univ., Japan).
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[Remarks] (7) Y. Watanabe, Y. Nakajima, T. Toyabe, T. Hanajiri, and T. Sugano,"Correlation between high-density trap stated and roughness at SOI/BOX interface in SIMOX wafers", 7^<th> Int. Symp. on Bioscience and Nanotechnology(2009) P. 45(20-21 Nov. 2009, Toyo Univ., Japan).
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[Remarks] (8) T. Tanimura, Y. Nakajima, and T. Hanajiri,"Photoluminescence study of Silicon-On-Quartz wafers for high performance Light-Emitting Transistors", 7^<th> Int. Symp. on Bio-science and Nanotechnology(2009) P. 48(20-21 Nov. 2009, Toyo Univ., Japan).
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[Remarks] (9) N. Takahashi, A. Aki, T. Ukai, Y. Nakajima, T. Maekawa and T. Hanajiri,"Electrophpretic Coulter Method for Simultaneous Measurement of Zeta Potential and distribution of Micro-particles Including Biological Cells in a Micro-channel", 7^<th> Int. Symp.on Bioscience and Nanotechnology(2009) P. 48(20-21 Nov. 2009, Toyo Univ., Japan).
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