2011 Fiscal Year Final Research Report
A basic study to develop the low-power laser therapy for Intractable epilepsies
| Project/Area Number |
21500416
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Soka University |
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Principal Investigator |
KOGURE Shinichi 創価大学, 大学院・工学研究科, 教授 (10133448)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 低出力レーザー / 難治性てんかん / 海馬スライス標本 / パッチクランプ法 / イオンチャネル / てんかん様発作波 / レーザー治療 |
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| Research Abstract |
The following results were obtained : i) The paroxysmal discharge threshold(PADT) was measured before and after low-power laser irradiation(LLI : 532nm, 50mW/80mW, 10min). LLIs increased the average PADT to 1.38(p<0.05)/1.94(p<0.01) times. ii) Using patch clamp technique, the effects of LLI on ion channels were examined. LLI affected not only the action potential with decreasing its threshold, but also the prolongation of inter-spike interval of repetitive firing. It is suggested that LLI has a potential to suppress the generation of burstic discharge via activating K+channels.
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