2011 Fiscal Year Final Research Report
Tissue formation of Wolffian duct cells, and generation of ureteric buds competent for nephron induction
| Project/Area Number |
21500424
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 中腎管 / FGF / レセプター / 成長因子 / 腎臓 / 再生 / 組織工学 / 相互作用 |
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| Research Abstract |
Wolffian duct is an essential tissue for kidney development, and ductal tissue formation of cultured Wolffian duct cells will be a key for kidney regeneration. In the present study, we examined gene expression of various grow factors in mesonephric tissues and their effects on Wolffian duct culture to assess their application for tissue engineering of the kidney. As a result, the potential of FGF was elucidated. FGF9 was shown to be expressed in mesonephric tissues and support the survival, proliferation and competence of Wolffian duct cells. A positive effect of FGF9 on primary culture of Wolffian duct cells was also verified.
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[Journal Article] The instructive role of metanephric mesenchyme in ureteric bud patterning, sculpting, and maturation and its potential ability to buffer ureteric bud branching defects2009
Author(s)
Shah MM, Tee JB, Meyer T, Meyer-Schwesinger C, Choi Y, Sweeney DE, Gallegos TF, Johkura K, Rosines E, Kouznetsova V, Rose DW, Bush KT, Sakurai H, Nigam SK
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Journal Title
Am J Physiol Renal Physiol
Volume: 297
Pages: 1330-1341
DOI
Peer Reviewed
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