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2011 Fiscal Year Final Research Report

Combined application of TMS/tDCS with intensive occupational therapy for upper limb hemiparesis

Research Project

  • PDF
Project/Area Number 21500493
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionJikei University School of Medicine

Principal Investigator

KAKUDA Wataru  東京慈恵会医科大学, 医学部, 講師 (00453788)

Co-Investigator(Kenkyū-buntansha) ABO Masahiro  東京慈恵会医科大学, 医学部, 教授 (00266587)
Project Period (FY) 2009 – 2011
Keywords経頭蓋磁気刺激 / 経頭蓋直流電気刺激 / 脳卒中 / 機能回復 / 上肢麻痺 / 作業療法 / 痙縮
Research Abstract

The main purpose of this study was to clarify the most beneficial therapeutic approach for upper limb hemiparesis after stroke among some modalities of repetitive transcranial magnetic stimulation(RTMS) and transcranial direct current stimulation(TDCS), and to investigate the clinical effect of combined application of RTMS/TDCS and intensive rehabilitative training. As a result, consecutive application of low-frequency RTMS over the non-lesional hemisphere with intensive occupational therapy was safe and seemed to have a potential to improve motor function of the affected upper limb in post-stroke patients. In addition, this combination significantly reduced abnormally increased muscle tonus of the affected upper limb, indicating the anti-spastic effect of the intervention. Unfortunately, the effect of TDCS on upper limb motor function after stroke has not been elucidated sufficiently so far, because of unexpected mechanical trouble with the device.

  • Research Products

    (17 results)

All 2012 2011 2010

All Journal Article (9 results) Presentation (6 results) Book (2 results)

  • [Journal Article] A multi-center study on low-frequency rTMS combined with intensive occupational therapy for upper limb hemiparesis after stroke2012

    • Author(s)
      Kakuda W, Abo M, Shimizu M, Sasanuma J, Okamoto T, Yokoi A, Taguchi K, Mitani S, Harashima H, Urushidani N, Urashima M
    • Journal Title

      Journal of NeuroEngineering and Rehabilitation

      Volume: 9 Pages: 4

  • [Journal Article] Application of combined 6-Hz primed low-frequency rTMS and intensive occupational therapy for upper limb hemiparesis after stroke2011

    • Author(s)
      Kakuda W, Abo M, Kobayashi K, Momosaki R, Yokoi A, Fukuda A, Umemori T
    • Journal Title

      NeuroRehabilitation

      Volume: 29 Pages: 365-371

  • [Journal Article] Outpatient application of repetitive transcranial magnetic stimulation and occupational therapy for upper limb hemiparesis after stroke : A pilot study2011

    • Author(s)
      Kakuda W, Abo M, Momosaki R, Yokoi A, Ito H, Ishikawa A, Taguchi K
    • Journal Title

      Jikeikai Medical Journal

      Volume: 58 Pages: 103-108

  • [Journal Article] Combined therapeutic application of botulinum toxin type A, low-frequency rTMS, and intensive occupational therapy for post-stroke spastic upper limb hemiparesis2011

    • Author(s)
      Kakuda W, Abo M, Momosaki R, Yokoi A, Fukuda A, Ito H, Tominaga A, Umemori T, Kameda Y
    • Journal Title

      Eur J Phys Rehabil Med

      Volume: 48 Pages: 47-55

  • [Journal Article] Combination treatment of low-frequency rTMS and occupational therapy with levodopa administration : an intensive neurorehabilitative approach for upper limb hemiparesis after stroke2011

    • Author(s)
      Kakuda W, Abo M, Kobayashi K, Momosaki R, Yokoi A, Fukuda A, Ito H, Tominaga A
    • Journal Title

      Int J Neurosci

      Volume: 121 Pages: 373-378

  • [Journal Article] Anti-spastic effect of low-frequency rTMS applied with occupational therapy in post-stroke patients with upper limb hemiparesis2011

    • Author(s)
      Kakuda W, Abo M, Kobayashi K, Momosaki R, Yokoi A, Fukuda A, Ito H, Tominaga A, Umemori T, Kameda Y
    • Journal Title

      Brain Injury

      Volume: 25 Pages: 496-502

  • [Journal Article] Baseline severity of upper limb hemiparesis influences the outcome of low-frequency rTMS combined with intensive occupational therapy in patients who have had a stroke2011

    • Author(s)
      Kakuda W, Abo M, Kobayashi K, Takagishi T, Momosaki R, Yokoi A, Fukuda A, Ito H, Tominaga A
    • Journal Title

      PMR

      Volume: 3 Pages: 516-522

  • [Journal Article] Low-frequency repetitive transcranial magnetic stimulation and intensive occupational therapy for poststroke patients with upper limb hemiparesis : preliminary study of a 15-day protocol2010

    • Author(s)
      Kakuda W, Abo M, Kobayashi K, Momosaki R, Yokoi A, Fukuda A, Ishikawa A, Ito H
    • Journal Title

      Int J Rehabil Res

      Volume: 33 Pages: 339-345

  • [Journal Article] Six-day course of repetitive transcranial magnetic stimulation plus occupational therapy for post-stroke patients with upper limb hemiparesis : A case series study2010

    • Author(s)
      Kakuda W, Abo M, Kaito N, Ishikawa A, Taguchi K, Yokoi A
    • Journal Title

      Disability and Rehabilitation

      Volume: 32 Pages: 801-807

  • [Presentation] 脳卒中後上肢麻痺に対する低頻度rTMSと集中的作業療法の併用療法~上肢麻痺の重症度別の検討2011

    • Author(s)
      角田亘, 他
    • Organizer
      第36回日本脳卒中学会総会
    • Place of Presentation
      京都
    • Year and Date
      20110700
  • [Presentation] Is the efficacy of low-frequency rTMS combined with intensive occupational therapy influenced by baseline severity of upper limb hemiparesis in post-stroke patients?2011

    • Author(s)
      Kakuda W, Abo M, Kobayashi K, Momosaki R, Yokoi A, Fukuda A, Ito H, Tominaga A
    • Organizer
      2011 International Stroke Conference
    • Place of Presentation
      Los Angeles
    • Year and Date
      20110200
  • [Presentation] 脳卒中後上肢麻痺に対する外来治療としての反復性経頭蓋磁気刺激と集中的作業療法の併用療法2010

    • Author(s)
      角田亘, 他
    • Organizer
      第47回日本リハビリテーション医学会学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      20100500
  • [Presentation] 脳卒中後上肢麻痺に対する低頻度経頭蓋磁気刺激と集中的作業療法の併用療法2010

    • Author(s)
      角田亘, 他
    • Organizer
      第35回日本脳卒中学会総会
    • Place of Presentation
      盛岡
    • Year and Date
      20100400
  • [Presentation] Low-frequency rTMS plus intensive occupational therapy improves motor function and reduces spasticity of paretic upper limb in post-stroke patients : A pilot study2010

    • Author(s)
      Kakuda W, Abo M, Kobayashi K, Momosaki R, Yokoi A, Fukuda A, Ishikawa A, Ito H
    • Organizer
      6th World Congress of Neurorehabilitation
    • Place of Presentation
      Vienna
    • Year and Date
      20100300
  • [Presentation] Combination treatment of low-frequency rTMS and intensive occupational therapy for post-stroke patients with upper limb hemiparesis2010

    • Author(s)
      Kakuda W, Abo M, Kobayashi K, Momosaki R, Yokoi A, Fukuda A
    • Organizer
      2010 International Stroke Conference
    • Place of Presentation
      San Antonio
    • Year and Date
      20100200
  • [Book] 上肢麻痺および失語症に対するrTMS治療. MB Medical Rehabilitation創刊10周年記念症例から学ぶ実践脳卒中リハビリテーション2011

    • Author(s)
      角田亘、安保雅博
    • Total Pages
      147-152
    • Publisher
      全日本病院出版会
  • [Book] 新たな治療手段TMSとは?他. rTMSと集中的作業療法による手指機能回復へのアプローチ2010

    • Author(s)
      角田亘
    • Total Pages
      39-49
    • Publisher
      三輪書店

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Published: 2013-07-31  

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