The improving effect of the redox capacity control upon maintainace hemodialysis patietnts' disability of locomotive function.

2011 Fiscal Year Final Research Report

• Project/Area Number: 21500532
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Fujita Health University
• Principal Investigator: OHASHI Atsushi 藤田保健衛生大学, 医療科学部, 准教授 (30310585)
• Co-Investigator(Kenkyū-buntansha): MURAKAMI Kazutaka 藤田保健衛生大学, 医学部, 講師 (30267950)
• Co-Investigator(Renkei-kenkyūsha): NAKAI Shigeru 藤田保健衛生大学, 医療科学部, 教授 (20345896)
• Project Period (FY): 2009 – 2011
• Keywords: 生体機能代行

Research Abstract

Firstly we investigated inhibition effect of the emodialysis using vitamin E-coated polysulfone membrane(VPS-HD) to the carbonylation of patients' plasma protein. Secondary we evaluated its influence on patients' health-rerated quality of life(HQOL) using SF-36.VPS-HD suppressed the carbonylation of their serum albumin, but not improve albumin's redox capacity. However VPS-HD gave no significant effect to physical functioning(PF), bodily pain(BP) or vitality(VT) of patient's HQOL, it significantly improved general healthy perceptions(GH). In addition, we found marginally significant positive correlation between its improvement of GH and its inhibition for serum albumin modification. These findings may suggest that VPS-HD ameliorates patient's GH throgh patietnt's redox capacity improvement.

Research Products

• [Journal Article] Comparison of Free Light Chain Removal by Four Blood Purification Methods (2011)
  • Author(s): Kanayama K, Ohashi A, Hasegawa M, Kondo F, Yamamoto Y, Sasaki M, Hayashi H, Kato K, Hattori R, Yamashita H, Arai J, Ishii J, Emi N, Yuzawa Y
  • Journal Title: Therapeutic Apheresis and Dialysis Volume: 15(4) Pages: 394-399
  • Peer Reviewed
• [Journal Article] Evaluation of blood purification and bortezomib plus dexamethasone therapy for the treatment of acute renal failure due to myeloma cast nephropathy (2010)
  • Author(s): Hasegawa M, Kondo F, Yamamoto K, Murakami K, Tomita M, Nabeshima K, Nakai S, Kato M, Ohashi A, Arai J, Hiki Y, Ishi J, Emi N, Sugiyama S, Yuzawa Y
  • Journal Title: Therapeutic Apheresis and Dialysis Volume: 14(5) Pages: 451-456
  • Peer Reviewed
• [Journal Article] ニプロ社製ダイアライザーPES-Seαecoの溶質除去特性とビスフェノールAの溶出に関する検討 (2010)
  • Author(s): 新典雄、村上和隆、石川正敏、橋詰英明、山田幸恵、加藤政雄、大橋篤、杉山敏
  • Journal Title: 腎と透析 Volume: Vol.69 Pages: 87-91
• [Journal Article] Expression of Tumor Necrosis Factor Receptors on Granulocytes in Patients with Myeloperoxidase Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis (2009)
  • Author(s): Hasegawa M, Nishii C, Ohashi A, Tomita M, Nakai S, Murakami K, Nabeshima K, Fujita Y, Ishii J, Hiki Y, Sugiyama S
  • Journal Title: Nephron Clin Pract Volume: 113(3) Pages: 222-233
  • Peer Reviewed
• [Presentation] 透析患者の血漿成分におけるDPPHラジカル捕捉能と酸化/還元型アルブミンによる抗酸化能の動態 (2010)
  • Author(s): 大橋篤, 堀秀生, 川口和紀, 中井滋, 北口暢哉, 比企能之, 村上和隆, 鍋島邦浩, 富田亮, 長谷川みどり, 杉山敏
  • Organizer: 日本透析医学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-06-17
• [Presentation] 維持透析患者における血清成分の窒素ラジカル供与物質に対する抗酸化能の評価 (2009)
  • Author(s): 大橋篤, 堀秀生, 中井滋, 村上和隆, 杉山敏
  • Organizer: 日本透析医学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-06-05