2011 Fiscal Year Final Research Report

The mechanism of exercise-induced increase in insulin sensitivity : Effect of exercise on NR4A receptor gene expression

Research Project

Project/Area Number	21500640
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Sports science
Research Institution	Niigata University of Health and Welfare
Principal Investigator	KAWANAKA Kentaro 新潟医療福祉大学, 健康科学部, 准教授 (80339960)
Co-Investigator(Renkei-kenkyūsha)	TERADA Shin 早稲田大学, 付置研究所, 講師 (00460048)
Project Period (FY)	2009 – 2011
Keywords	骨格筋 / インスリン感受性 / 遺伝子
Research Abstract	Exercise increases insulin sensitivity of glucose transport in skeletal muscle. Our study aimed to examine the possibility that exercise-induced increase in insulin sensitivity is mediated by the increased expression of NR4A receptors in skeletal muscle. However, this possibility is unlikely since exercise increased NR4A mRNA but not protein expression in rat skeletal muscle. On the other hand, our study showed that hindlimb immobilization decreased NR4A protein expression in rat postural muscle, suggesting the possibility that inactivity-induced insulin resistance is mediated by the reduced expression of NR4A receptors.