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2013 Fiscal Year Final Research Report

Cohort study and preventive approach for knee osteoarthrits and anterior cruciate ligament injury

Research Project

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Project/Area Number 21500676
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionHirosaki University

Principal Investigator

ISHIBASHI Yasuyuki  弘前大学, 医学(系)研究科(研究院), 教授 (80292142)

Co-Investigator(Kenkyū-buntansha) TSUDA Eiichi  弘前大学, 医学部附属病院, 准教授 (00361014)
YAMAMOTO Yuji  弘前大学, 医学部附属病院, 助教 (10529671)
NAHAJI Shigeyuki  弘前大学, 医学研究科, 教授 (10192220)
TOH Satoshi  弘前大学, 医学研究科, 教授 (30142863)
UMEDA Takashi  弘前大学, 医学研究科, 准教授 (50311535)
Co-Investigator(Renkei-kenkyūsha) NUMASAWA Takuya  弘前大学, 医学研究科, 助教 (80396407)
ONO Atushi  弘前大学, 医学部附属病院, 講師 (40400155)
WADA Kanichiro  弘前大学, 医学部附属病院, 助教 (20431447)
TANAKA Toshihiro  弘前大学, 医学研究科, 助教 (20613334)
MAEDA Shuugo  弘前大学, 医学部附属病院, 助手 (70568906)
KIMURA Yuka  弘前大学, 医学部附属病院, 医員 (40455746)
INOUE Ryou  弘前大学, 医学部附属病院, 医員 (50455747)
IWASAKI Hiroki  弘前大学, 医学部附属病院, 医員 (80529678)
SASAKI Eiji  弘前大学, 医学部附属病院, 医員 (60587038)
SASAKI Shizuka  弘前大学, 医学部附属病院, 医員 (20587042)
OOISHI Kazuki  弘前大学, 医学部附属病院, 医員 (60724846)
CHIBA Daisuke   (70587055)
Project Period (FY) 2009-04-01 – 2014-03-31
Keywords変形性膝関節症 / 膝前十字靭帯 / 予防 / 疫学
Research Abstract

Iwaki Health Promotion Project revealed that the risk factors for knee osteoarthritis were aging, female, obesity, and metabolic syndrome. Furthermore, the presence of knee pain causes locomotive syndrome. Serum hyaluronan is a biomarker for knee osteoarthritis, and its elevation predicted progression of knee osteoarthritis. Also, effect of exercise therapy for knee osteoarthritis was less in those with higher serum hyaluronan.
Valgus alignment was risk for ACL injury. In pubertal, valgus alignment of females is larger than males, and its angle become progressed with aging. On the contrary, preventive training approach for trunk stability (10 minutes training, 4 times a week) was effective. At landing, trunk bending angle increased, valgus moment decreased and trunk lateral instability decreased. Trunk stabilizing training for pubertal age has potential to prevent ACL injury.

  • Research Products

    (13 results)

All 2014 2013 2012 2011 2010 2009

All Journal Article (8 results) Presentation (5 results)

  • [Journal Article] Nocturnal knee pain increases with the severity of knee osteoarthritis, disturbing patient sleep quality2014

    • Author(s)
      Sasaki E, Tsuda E, Yamamoto Y, Maeda S,Inoue R, Chiba D, Takahashi I, Okubo N, Nakaji S, Ishibashi Y
    • Journal Title

      Arthritis Care Res

      Volume: (epub ahead)

  • [Journal Article] Change with increasing age in control of the lower limbs during jump-landing in adolescents : a 5-year prospective study2013

    • Author(s)
      Sasaki S, Tsuda E, Yamamoto Y, Maeda S, Hayashi Y, Kimura Y, Sasaki E, Fujita Y, Takahashi I, Umeda T, Nakaji S, Ishibashi Y
    • Journal Title

      J Orthop Sci

      Volume: 18(5) Pages: 774-781

  • [Journal Article] Evaluation of locomotive disability by using Loco-check : the cross sectional study in Japanese general population2013

    • Author(s)
      Sasaki E, Ishibashi Y, Tsuda E, Yamamoto Y, Ono A, Inoue R, Takahashi I, Umeda T, Nakaji S
    • Journal Title

      J Orthop Sci

      Volume: 18(1) Pages: 121-129

  • [Journal Article] Serum hyaluronan levels increase with the total number of osteoarthritic joints, and are strongly correlated to the presences of knee and finger osteoarthritis2013

    • Author(s)
      Sasaki E, Tsuda E, Yamamoto Y, Iwasaki K, Inoue R, Takahashi I, Sawada K, Fujita H, Umeda T, Nakaji S, and Ishibashi Y
    • Journal Title

      Int Orthop

      Volume: 37(5) Pages: 925-930

  • [Journal Article] Increased knee valgus alignment and moment during single-leg landing after overhead stroke as a potential risk factor of anterior cruciate ligament injury in badminton2012

    • Author(s)
      Kimura Y, Ishibashi Y, Tsuda E, Yamamoto Y, Hayashi Y, Sato S
    • Journal Title

      Br J Sports Med

      Volume: 46(3) Pages: 207-213

  • [Journal Article] Increased Knee Valgus Alignment and Moment During Single Leg Landing After Overhead Stroke as a Potential Risk Factor of Anterior Cruciate Ligament Injury in Badminton2012

    • Author(s)
      Kimua Y, Ishibashi Y, Tsuda E, Yamamoto Y, Hayashi Y, Sato S
    • Journal Title

      Br J Sports Med.

      Volume: 46(3) Pages: 207-213

  • [Journal Article] Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population2011

    • Author(s)
      Inoue R, Ishibashi Y, Tsuda E, Yamamoto Y, Matsuzaka M, Takahashi I, Danjo K, Umeda T, Nakaji S, Toh S
    • Journal Title

      Osteoarthritis Cartilage

      Volume: 19(1) Pages: 51-57

  • [Journal Article] Medical problems and risk factors of metabolic syndrome among radiographic knee osteoarthritis patients in the Japanese general population2011

    • Author(s)
      Inoue R, Ishibashi Y, Tsuda E, Yamamoto Y, Matsuzaka M, Takahashi I, Danjo K, Umeda T, Nakaji S, Toh S
    • Journal Title

      J Orthop Sci

      Volume: 16(6) Pages: 704-709

  • [Presentation] 思春期における着地動作中の動的下肢アライメントの経時的変化2012

    • Author(s)
      佐々木静, 津田英一, 山本祐司, 前田周吾, 木村由佳, 佐々木英嗣, 藤田有紀, 石橋恭之
    • Organizer
      第39回日本臨床バイオメカニクス学会
    • Place of Presentation
      幕張市
    • Year and Date
      20121109-10
  • [Presentation] 変形性膝関節症と変形性脊椎症のロコモティブシンドロームへの影響の検討2011

    • Author(s)
      佐々木英嗣, 石橋恭之, 津田英一, 小野睦, 山本祐司, 井上亮, 他5名
    • Organizer
      第39回日本関節病学会
    • Place of Presentation
      横浜
    • Year and Date
      20111111-12
  • [Presentation] 変形性膝関節症罹患者におけるメタボリックシンドロームの合併率2010

    • Author(s)
      井上亮, 石橋恭之, 津田英一, 山本祐司, 前田周吾, 松坂方士, 他5名
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      20101014-15
  • [Presentation] Relationship between knee osteoarthritis and serum concentration of byaluronan in the general population2010

    • Author(s)
      井上亮、石橋恭之, 他8名
    • Organizer
      Annual Meeting of Orthopaedic Research Society
    • Place of Presentation
      New Orleans
    • Year and Date
      20100306-09
  • [Presentation] 小学校高学年における着地動作中の動的下肢アライメントの変化2009

    • Author(s)
      木村由佳、石橋恭之, 他5名
    • Organizer
      日本関節鏡・膝・スポーツ整形外科学会(JOSKAS)
    • Place of Presentation
      札幌
    • Year and Date
      20090625-27

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Published: 2015-07-16  

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