Cohort study and preventive approach for knee osteoarthrits and anterior cruciate ligament injury

2013 Fiscal Year Final Research Report

• Project/Area Number: 21500676
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Hirosaki University
• Principal Investigator: ISHIBASHI Yasuyuki 弘前大学, 医学(系)研究科(研究院), 教授 (80292142)
• Co-Investigator(Kenkyū-buntansha): TSUDA Eiichi 弘前大学, 医学部附属病院, 准教授 (00361014) ; YAMAMOTO Yuji 弘前大学, 医学部附属病院, 助教 (10529671) ; NAHAJI Shigeyuki 弘前大学, 医学研究科, 教授 (10192220) ; TOH Satoshi 弘前大学, 医学研究科, 教授 (30142863) ; UMEDA Takashi 弘前大学, 医学研究科, 准教授 (50311535)
• Co-Investigator(Renkei-kenkyūsha): NUMASAWA Takuya 弘前大学, 医学研究科, 助教 (80396407) ; ONO Atushi 弘前大学, 医学部附属病院, 講師 (40400155) ; WADA Kanichiro 弘前大学, 医学部附属病院, 助教 (20431447) ; TANAKA Toshihiro 弘前大学, 医学研究科, 助教 (20613334) ; MAEDA Shuugo 弘前大学, 医学部附属病院, 助手 (70568906) ; KIMURA Yuka 弘前大学, 医学部附属病院, 医員 (40455746) ; INOUE Ryou 弘前大学, 医学部附属病院, 医員 (50455747) ; IWASAKI Hiroki 弘前大学, 医学部附属病院, 医員 (80529678) ; SASAKI Eiji 弘前大学, 医学部附属病院, 医員 (60587038) ; SASAKI Shizuka 弘前大学, 医学部附属病院, 医員 (20587042) ; OOISHI Kazuki 弘前大学, 医学部附属病院, 医員 (60724846) ; CHIBA Daisuke (70587055)
• Project Period (FY): 2009-04-01 – 2014-03-31
• Keywords: 変形性膝関節症 / 膝前十字靭帯 / 予防 / 疫学

Research Abstract

Iwaki Health Promotion Project revealed that the risk factors for knee osteoarthritis were aging, female, obesity, and metabolic syndrome. Furthermore, the presence of knee pain causes locomotive syndrome. Serum hyaluronan is a biomarker for knee osteoarthritis, and its elevation predicted progression of knee osteoarthritis. Also, effect of exercise therapy for knee osteoarthritis was less in those with higher serum hyaluronan.
Valgus alignment was risk for ACL injury. In pubertal, valgus alignment of females is larger than males, and its angle become progressed with aging. On the contrary, preventive training approach for trunk stability (10 minutes training, 4 times a week) was effective. At landing, trunk bending angle increased, valgus moment decreased and trunk lateral instability decreased. Trunk stabilizing training for pubertal age has potential to prevent ACL injury.

Research Products

• [Journal Article] Nocturnal knee pain increases with the severity of knee osteoarthritis, disturbing patient sleep quality (2014)
  • Author(s): Sasaki E, Tsuda E, Yamamoto Y, Maeda S,Inoue R, Chiba D, Takahashi I, Okubo N, Nakaji S, Ishibashi Y
  • Journal Title: Arthritis Care Res Volume: (epub ahead)
• [Journal Article] Change with increasing age in control of the lower limbs during jump-landing in adolescents : a 5-year prospective study (2013)
  • Author(s): Sasaki S, Tsuda E, Yamamoto Y, Maeda S, Hayashi Y, Kimura Y, Sasaki E, Fujita Y, Takahashi I, Umeda T, Nakaji S, Ishibashi Y
  • Journal Title: J Orthop Sci Volume: 18(5) Pages: 774-781
• [Journal Article] Evaluation of locomotive disability by using Loco-check : the cross sectional study in Japanese general population (2013)
  • Author(s): Sasaki E, Ishibashi Y, Tsuda E, Yamamoto Y, Ono A, Inoue R, Takahashi I, Umeda T, Nakaji S
  • Journal Title: J Orthop Sci Volume: 18(1) Pages: 121-129
• [Journal Article] Serum hyaluronan levels increase with the total number of osteoarthritic joints, and are strongly correlated to the presences of knee and finger osteoarthritis (2013)
  • Author(s): Sasaki E, Tsuda E, Yamamoto Y, Iwasaki K, Inoue R, Takahashi I, Sawada K, Fujita H, Umeda T, Nakaji S, and Ishibashi Y
  • Journal Title: Int Orthop Volume: 37(5) Pages: 925-930
• [Journal Article] Increased knee valgus alignment and moment during single-leg landing after overhead stroke as a potential risk factor of anterior cruciate ligament injury in badminton (2012)
  • Author(s): Kimura Y, Ishibashi Y, Tsuda E, Yamamoto Y, Hayashi Y, Sato S
  • Journal Title: Br J Sports Med Volume: 46(3) Pages: 207-213
• [Journal Article] Increased Knee Valgus Alignment and Moment During Single Leg Landing After Overhead Stroke as a Potential Risk Factor of Anterior Cruciate Ligament Injury in Badminton (2012)
  • Author(s): Kimua Y, Ishibashi Y, Tsuda E, Yamamoto Y, Hayashi Y, Sato S
  • Journal Title: Br J Sports Med. Volume: 46(3) Pages: 207-213
• [Journal Article] Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population (2011)
  • Author(s): Inoue R, Ishibashi Y, Tsuda E, Yamamoto Y, Matsuzaka M, Takahashi I, Danjo K, Umeda T, Nakaji S, Toh S
  • Journal Title: Osteoarthritis Cartilage Volume: 19(1) Pages: 51-57
• [Journal Article] Medical problems and risk factors of metabolic syndrome among radiographic knee osteoarthritis patients in the Japanese general population (2011)
  • Author(s): Inoue R, Ishibashi Y, Tsuda E, Yamamoto Y, Matsuzaka M, Takahashi I, Danjo K, Umeda T, Nakaji S, Toh S
  • Journal Title: J Orthop Sci Volume: 16(6) Pages: 704-709
• [Presentation] 思春期における着地動作中の動的下肢アライメントの経時的変化 (2012)
  • Author(s): 佐々木静, 津田英一, 山本祐司, 前田周吾, 木村由佳, 佐々木英嗣, 藤田有紀, 石橋恭之
  • Organizer: 第39回日本臨床バイオメカニクス学会
  • Place of Presentation: 幕張市
  • Year and Date: 20121109-10
• [Presentation] 変形性膝関節症と変形性脊椎症のロコモティブシンドロームへの影響の検討 (2011)
  • Author(s): 佐々木英嗣, 石橋恭之, 津田英一, 小野睦, 山本祐司, 井上亮, 他5名
  • Organizer: 第39回日本関節病学会
  • Place of Presentation: 横浜
  • Year and Date: 20111111-12
• [Presentation] 変形性膝関節症罹患者におけるメタボリックシンドロームの合併率 (2010)
  • Author(s): 井上亮, 石橋恭之, 津田英一, 山本祐司, 前田周吾, 松坂方士, 他5名
  • Organizer: 第25回日本整形外科学会基礎学術集会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 20101014-15
• [Presentation] Relationship between knee osteoarthritis and serum concentration of byaluronan in the general population (2010)
  • Author(s): 井上亮、石橋恭之, 他8名
  • Organizer: Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: New Orleans
  • Year and Date: 20100306-09
• [Presentation] 小学校高学年における着地動作中の動的下肢アライメントの変化 (2009)
  • Author(s): 木村由佳、石橋恭之, 他5名
  • Organizer: 日本関節鏡・膝・スポーツ整形外科学会(JOSKAS)
  • Place of Presentation: 札幌
  • Year and Date: 20090625-27