2011 Fiscal Year Final Research Report
The role of TFE3, a metabolism-related transcription factor, in skeletal muscles.
| Project/Area Number |
21500677
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Ochanomizu University (2010-2011)
University of Tsukuba (2009) |
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Principal Investigator |
IIDA Kaoruko お茶の水女子大学, 大学院・人間文化創成科学研究科, 准教授 (50375458)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Yoshimi 筑波大学, 大学院・人間総合科学研究科, 講師 (80361351)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 生活習慣病 |
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| Research Abstract |
In this study, we investigated the roles of TFE3 in skeletal muscle, the main organ for energy metabolism, using transgenic mice overexpressing TFE3 in muscles. In TFE3 transgenic muscle, glycogen stores were more than 2-fold than wild-type, and this was associated with an upregulation of genes involved in glucose metabolism, specifically GLUT4, HK2 and GYS. Consequently, exercise endurance capacity was enhanced in this transgenic model. Furthermore, insulin sensitivity was enhanced in transgenic mice, and exhibited better improvement after 4 weeks of exercise training.
These potential roles of TFE3 in regulating metabolic genes and glucose metabolism within skeletal muscle suggests that it may be used for treating metabolic diseases, as well as increasing endurance in sport.
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[Journal Article] TFE3 Regulates Muscle Metabolic Gene Expression, Increases Glycogen Stores, and Enhances Insulin Sensitivity in Mice2012
Author(s)
Iwasaki H, Naka A, Iida KT, Nakagawa Y, Matsuzaka T, Ishii KA, Kobayashi K, Takahashi A, Yatoh S, Yahagi N, Sone H, Suzuki H, Yamada N, Shimano H.
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302(7)
Pages: E896-902q
Peer Reviewed
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