Identification of the exercise not for bone formation but for bone absorption suppression and investigation of the underlying mechanisms

2011 Fiscal Year Final Research Report

• Project/Area Number: 21500681
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kanazawa University
• Principal Investigator: KITAMURA Kei-ichiro 金沢大学, 保健学系, 准教授 (80283117)
• Co-Investigator(Kenkyū-buntansha): IKEGAME Mika 岡山大学, 医歯薬学総合研究科, 准教授 (70282986) ; TAKASAKI Ichiro 富山大学, 生命科学先端研究センター, 助教 (00397176)
• Project Period (FY): 2009 – 2011
• Keywords: 運動処方と運動療法 / 骨粗鬆症 / 破骨細胞 / 骨芽細胞 / マウス / 頭蓋骨 / バイブレーション / 運動加速度記録システム

Research Abstract

To investigate the effects of low intensity vibration on the enzyme activities and the gene expression for both bone absorption and formation, we cultivated neonatal mouse calvaria as human bone model. Mice calvaria treated with 0. 5-and 2. 0-G vibrational acceleration showed a significant inhibition of osteoclast enzyme activity and an increase of expression of type I collagen. We also found that slow walking generates 0. 5-G or more acceleration at the waist. Therefore, our results suggested that not only high-intensity strength exercises such as jumping, but frequent walking can decrease bone absorption activity in the weight bearing bone of the waist in elderly.

Research Products

• [Journal Article] Effects of inorganic mercury on osteoclasts and osteoblasts of the goldfish scales in an in vitro (2011)
  • Author(s): Suzuki, N., Yachiguchi, K., Hayakawa, K., Takada, K., Tabata, M. J., Kitamura, K., Srivastav, A. K., Chowdhury, V. S., Oshima, Y., Hattori, A.
  • Journal Title: J. Fac. Agr. Kyushu U Volume: 56 Pages: 47-51
  • Peer Reviewed
• [Journal Article] Acceleration-based study of optimum exercise for human weight-bearing bones enhancement (2010)
  • Author(s): Kitamura, K., Chen, W., Zhu, X., Suzuki, N., Yano, S., Nemoto, T.
  • Journal Title: Biological Sciences in Space Volume: 24 Pages: 83-90
  • Peer Reviewed
• [Journal Article] Toxic effect of polycyclic aromatic hydrocarbon metabolites on fish bone metabolism (2010)
  • Author(s): Hayakawa, K., Suzuki, N., Kitamura, K., Bekki, K., Nakano, J., Yoshita, M., Toriba, A., Kameda, T., Tang, N.
  • Journal Title: WIT Transactions on Ecology and the Environment Volume: 135 Pages: 231-241
  • Peer Reviewed
• [Journal Article] Effects of low-intensity ultrasound on osteoblasts and osteoclasts in goldfish scale (2010)
  • Author(s): Kitamura, K
  • Journal Title: Biological Sciences in Space Volume: 24 Pages: 29-34
  • Peer Reviewed
• [Journal Article] Osteoblast activity in the goldfish scale responds sensitively to mechanical stress (2010)
  • Author(s): Kitamura, K., Suzuki, N., Sato, Y., Nemoto, T., Ikegame, M., Yamamoto, T., Shimizu, N., Kondo, T., Furusawa, Y., Shigehito Wada, S., Hattori, A.
  • Journal Title: Comp. Biochem. Physiol. A Volume: 156 Pages: 357-363
  • Peer Reviewed
• [Journal Article] Long-term monitoring of heart rate, respiration rhythm, and body movement during sleep based on network (2010)
  • Author(s): Zhu, X., Chen, W., Nemoto, T., Kitamura, K., and Wei, D.
  • Journal Title: Telemedicine and e-Health Volume: 16 Pages: 244-253
  • Peer Reviewed
• [Journal Article] Development of a new method for the noninvasive measurement of deep body temperature without a heater (2010)
  • Author(s): Kitamura, K., Zhu, X., Chen, W., Nemoto, T.
  • Journal Title: Medical Engineering and Physics Volume: 32 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Response of osteoblasts and osteoclasts in regenerating scales to gravity loading using an assay system developed with regenerating scales (2009)
  • Author(s): Suzuki, N., Kitamura, K., et al.
  • Journal Title: Biological Sciences in Space Volume: 23 Pages: 211-217
  • Peer Reviewed
• [Journal Article] Development of a new accelerometer based physical activity-monitoring system using a high-frequency sampling rate (2009)
  • Author(s): Kitamura, K., Nemoto, T., Sato, N., Chen, W.
  • Journal Title: Biological Sciences in Space Volume: 32 Pages: 77-83
  • Peer Reviewed
• [Presentation] Teleost Scale metabolite profiling reveals differential changes in response to gravitational stress (2010)
  • Author(s): Maeda, M., Hayashi, A., Nakamura, S., Serino, T., Kitamura, K., Suzuki, N.
  • Organizer: 58th American Society for Mass Spectrometry conference on Mass Spectro metory Conference
  • Place of Presentation: Salt Lake City, Utah, USA
  • Year and Date: 20100523-27
• [Presentation] Investigation of the effects of low-intensity ultrasound on bone metabolism in the scale of goldfish(Carassius auratus) (2009)
  • Author(s): Kitamura, K.
  • Organizer: JSBSS23
  • Place of Presentation: Japan
  • Year and Date: 20091002-03
• [Remarks]
  • URL: http://kurt.kanazawa-u.ac.jp/souran_ku/info_e.php?teacher_id=439