2011 Fiscal Year Final Research Report
Molecular mechanisms of glucose metabolism induced by stretch in skeletal muscles.
| Project/Area Number |
21500687
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | University of Shizuoka |
|---|
Principal Investigator |
OBARA Kazuo 静岡県立大学, 薬学部, 講師 (60117611)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 骨格筋 / 糖代謝 / ストレッチ / インテグリン / カルシウム / GLUT4 / CaMKII |
|---|
| Research Abstract |
Mechanism of glucose uptake induced by passive stretch stimulation(stretch) in skeletal muscle was investigated. Our results suggest that stretch is accepted by integrin/FAK and causes Ca^<2+> release from sarcoplasmic reticulum, resulting increase in glucose uptake through CaMKII activation. Our results also suggest that stretch-induced glucose uptake involves insulin-and contraction-independent pathways.
|
