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2011 Fiscal Year Final Research Report

Applied research on the relationship between bacterial/viral infections and reduction of exercise performance

Research Project

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Project/Area Number 21500700
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionKawasaki University of Medical Welfare

Principal Investigator

YANO Hiromi  川崎医療福祉大学, 医療技術学部, 准教授 (20248272)

Project Period (FY) 2009 – 2011
Keywords病原体関連分子 / TLRs / 疲労困憊運動 / 自発運動 / マウス
Research Abstract

We have shown that protection against bacterial and/or viral infections is inhibited by an intense exercise, and physical activity is inhibited by the immune defense function after infection. Immunosuppression due to the intense exercise is a reasonable reaction defense to minimize the inflammation with a focus on skeletal muscle after exercise. On the other hand, the regulation of physical activity by the immune function saves energy consumption, and that is a system that gives higher priority to energy use for immune reaction.

  • Research Products

    (16 results)

All 2012 2011 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (12 results) Book (1 results)

  • [Journal Article] Interferon-beta, but not tumor necrosis factor-alpha, production in response to poly I : C is maintained despite exhaustive exercise in mice2012

    • Author(s)
      Uchida M, Oyanagi E, Kremenik MJ, Sasaki J, Yano H
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 62 Pages: 59-62

    • DOI

      DOI:10.1007/s12576-011-0177-4

    • Peer Reviewed
  • [Journal Article] Exhaustive exercise reduces TNF-α and IFN-α production in response to R-848 via toll-like receptor 7 in mice2010

    • Author(s)
      Yano H, Uchida M, Nakai R, Kawanishi N, Kato Y, Kremenik MJ, Shiva D
    • Journal Title

      European Journal of Applied Physiology

      Volume: 110 Pages: 797-803

    • DOI

      DOI:10.1007/s00421-010-1560-1

    • Peer Reviewed
  • [Journal Article] Exhaustive exercise reduces tumor necrosis factor-alpha production in response to lipo-polysaccharide in mice2010

    • Author(s)
      Tanaka Y, Kawanishi N, Shiva D, Tsutsumi N, Uchida M, Kitamura H, Kato Y, Yano H
    • Journal Title

      NeuroImmuno-Modulation

      Volume: 17 Pages: 279-286

    • DOI

      DOI:10.1159/000290044

    • Peer Reviewed
  • [Presentation] 筋損傷後の炎症・修復過程におけるマクロファージ走化性と分化の関連性2011

    • Author(s)
      矢野博己
    • Organizer
      第68回日本体力医学会中国・四国地方会
    • Place of Presentation
      島根大学教育学部(島根県)
    • Year and Date
      2011-11-12
  • [Presentation] オープンウィンドウ回復時の身体活動性2011

    • Author(s)
      矢野博己
    • Organizer
      第66回日本体力医学会大会
    • Place of Presentation
      海峡メッセ下関(山口県)
    • Year and Date
      2011-09-18
  • [Presentation] Moderate exercise training do not improve LPS-induced TNF-alpha reduction after exhaustive exercise2011

    • Author(s)
      Kitamura H
    • Organizer
      The 10th International Society of Exercise and Immunology(ISEI) Symposium
    • Place of Presentation
      University of Oxford(UK)
    • Year and Date
      2011-07-12
  • [Presentation] 医,食,運動:健康で長生きするために健康をもとめて-免疫学がおしえてくれた運動の不思議-2011

    • Author(s)
      矢野博己
    • Organizer
      おかやまバイオアクティブ研究会第39回シンポジウム(招待講演)
    • Place of Presentation
      川崎医科大学(岡山県)
    • Year and Date
      2011-06-10
  • [Presentation] シンポジウム「自然免疫と感染防御-Toll like receptorを介した免疫応答と運動-」2011

    • Author(s)
      矢野博己
    • Organizer
      第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
    • Year and Date
      2011-03-30
  • [Presentation] オープンウィンドウ学説の解明-TNF-αを指標として-2010

    • Author(s)
      矢野博己
    • Organizer
      第66回日本体力医学会中国・四国地方会
    • Place of Presentation
      徳島大学(徳島県)
    • Year and Date
      2010-11-21
  • [Presentation] LPS誘導性TNF-α産生は疲労困憊運動によって抑制される2010

    • Author(s)
      矢野博己
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学(千葉県)
    • Year and Date
      2010-09-18
  • [Presentation] 教育講演「運動免疫学から個体差を考える」2010

    • Author(s)
      矢野博己
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学(千葉県)
    • Year and Date
      2010-09-17
  • [Presentation] シンポジウム「細菌およびウイルスモデルに対する免疫応答と運動」2010

    • Author(s)
      矢野博己
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大学(千葉県)
    • Year and Date
      2010-09-17
  • [Presentation] The response of voluntary physical activity to R-848 via TLR7 in mice2010

    • Author(s)
      Yano H
    • Organizer
      57th Annual Meeting of The American College of Sports Medicine
    • Place of Presentation
      Baltimore(USA)
    • Year and Date
      2010-06-04
  • [Presentation] Exhaustive exercise reduces TNF-alpha and IFN-gamma production in response to R-848 via toll-like receptor 7 in mice2009

    • Author(s)
      Yano H
    • Organizer
      9th Symposium of the International Society of Exercise and immunology
    • Place of Presentation
      Tubingen(Germany)
    • Year and Date
      2009-09-22
  • [Presentation] The response of voluntary physical activity via TLR3 and TLR7/8 in mice2009

    • Author(s)
      Yano H
    • Organizer
      56th Annual Meeting of The American College of Sports Medicine
    • Place of Presentation
      Seattle(USA)
    • Year and Date
      2009-05-27
  • [Book] 運動生理学のニューエビデンス2010

    • Author(s)
      宮村実晴(編)矢野博己, 他
    • Total Pages
      442-450
    • Publisher
      真興交易(株)医書出版部

URL: 

Published: 2013-07-31  

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