2011 Fiscal Year Final Research Report
Development and the application of a comprehensive cause-analysis system for hypertriglyceridemia that is a risk factor for coronary heart disease
| Project/Area Number |
21500702
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
TAKAGI Atsuko 独立行政法人国立循環器病研究センター, 分子薬理部, 室長 (90179416)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Yasuyuki 独立行政法人国立循環器病研究センター, 分子薬理部, 客員研究員 (90176107)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 高トリグリセリド血症 / リポ蛋白リパーゼ / 動脈硬化 / 心疾患 / 自己免疫性疾患 / 全身性エリテマトーデス |
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| Research Abstract |
Hypertriglyceridemia is one of the risk factors for coronary heart disease, and it is caused by an abnormality of lipoprotein lipase(LPL) that is mainly associated with catabolism of triglyceride in the circulation. In fact, we found a compound heterozygous LPL deficiency of S193R/I194T as a cause of hypertriglyceridemia in a subject with the low level of LPL activity and LPL protein. However, there was a case whose LPL gene had no abnormality in spite of the low level of LPL both activity and protein. In this case, we found an inhibitor of LPL enzyme in the patient's plasma. Detection of the inhibitor was done by a combination of the method of measuring inhibitory effect of the plasma on LPL activity and determining a typeof the immunoglobulin binding to LPL protein by Western blot method. Measurement of the inhibition of the functional LPL activity by plasma was essential for the detection of inhibitors of LPL enzyme.
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Research Products
(8 results)
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[Presentation] Hypertriglyceridemia(HTG) caused by autoantibodies to lipoprotein lipase(LPL) in a patient with systemic lupus erythematosus(SLE)2011
Author(s)
Atsuko Takagi, Yasuyuki Ikeda, Mariko Araki, Taku Morita, Masayuki Ishihara, Manabu Matsumoto, Hisashi Takasugi, Akihiko Maeda, Takanori Abe, Mikiya Fujieda, and Hiroshi Wakiguchi
Organizer
第43回日本動脈硬化学会大会
Place of Presentation
札幌・ロイトンホテル
Year and Date
2011-07-16
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