2011 Fiscal Year Final Research Report
Study of the effect of rare metals on iNKT cells by molecular nutritional procedure
| Project/Area Number |
21500789
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits, studies on eating habits
|
|---|
| Research Institution | Takasaki University of Health and Welfare |
|---|
Principal Investigator |
TANAKA Susumu 高崎健康福祉大学, 健康福祉学部, 教授 (70348142)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | レアメタル / カルシニューリン / インターロイキン-2 / Jurkat細胞 / 転写調節因子 / 細胞性免疫 |
|---|
| Research Abstract |
In vitro screening was performed for trace elements and rare metals that influence the enzyme activity of calcineurin(CN), which is involved in cellular immunity. Manganese(Mn^<2+>) noncompetitively inhibited nickel(Ni^<2+>)-stimulated CN activity, and the rare earth lanthanum(La^<3+>) increased CN activity. Next, the influence of vanadium ion(VO)^<3->_4) on the production of interleukin-2(IL-2)(an indicator of cellular immunity) was investigated using the human T-cell line Jurkat cells. This showed that NADPH oxidase-mediated VO^<3->_4induced IL-2 production in Jurkat T-cells.
|
