2011 Fiscal Year Final Research Report
Induction of ovalbumin-specific allergic reaction by ingestion of food additives including aluminum
| Project/Area Number |
21500796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 健康と食生活 / 食品衛生 |
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| Research Abstract |
In this study, we investigated whether the ingestion of aluminum potassium sulfate(APS) in food additives is involved in the triggering and development of allergies. Our research was conducted through animal experimentation and surveys. Oral administration of APS activated dendritic cells in the mesenteric lymph nodes in mice. Furthermore, production of ovalbumin(OVA)-specific antibodies and T cell proliferative responses were enhanced by oral administration of OVA and APS. We also showed that women with allergies consume foods with APS more frequently than woman without allergies. Thus, it was demonstrated that ingestion of APS enhanced immune responses and may contribute to the triggering and development of allergic reactions in mice and humans.
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