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2011 Fiscal Year Final Research Report

The health effects of dietary glycated protein by ascorbic acid

Research Project

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Project/Area Number 21500797
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionTokyo Kasei Gakuin University (2011)
Nigata University of Phermacy and Applied Life Sciences (2009-2010)

Principal Investigator

MIYAKE Noriko  東京家政学院大学, 現代生活学部, 准教授 (70314573)

Co-Investigator(Kenkyū-buntansha) SUZUKI Emiko  お茶の水女子大学, 大学院・人間文化創生科学研究科, 教授 (80154524)
Project Period (FY) 2009 – 2011
KeywordsビタミンC / 酸化 / メイラード反応 / 加熱調理 / AGE受容体 / 安全性
Research Abstract

The health effects of food-derived glycated casein by ascorbic acid(AsA) oxidation products were in vitro investigated. AsA, 2, 3-diketogulonic acid(DKG), glucose, glyoxal(GO) and methylglyoxal(MGO) were heated with casein, and their yields of glycated products were determined. Formation of DKG-casein was at similar level to GO-and MGO-casein. The cytotoxicity of DKG-casein was examined using intestinal cell line Caco-2.The larger inhibitory effect in Caco-2 cellular proliferation by DKG-casein was observed than GO-and MGO-casein. The expression of the receptor for advanced glycation endproducts(RAGE) mRNA in Caco-2 was studied. Stimulation of Caco-2 with DKG-casein resulted in a significant increase in RAGE mRNA expression. Therefore, dietary ascorbic acid-derived glycation products might have a risk for human health and the effect was suggested to be mediated by RAGE.

  • Research Products

    (1 results)

All 2011

All Presentation (1 results)

  • [Presentation] 食品の調理・加工過程におけるビタミンC由来グリケーション反応生成物の健康への影響2011

    • Author(s)
      三宅紀子、酒井清子、松井裕巳、吉川巧、鈴木恵美子、倉田忠男
    • Organizer
      日本調理科学会
    • Place of Presentation
      高崎健康福祉大学
    • Year and Date
      2011-08-30

URL: 

Published: 2013-07-31  

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