2011 Fiscal Year Final Research Report
Effects of capsaicin or gingerol on preventing the onset and progression of hypertension
| Project/Area Number |
21500805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Kobe Women's University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Hiroko 大阪成蹊短期大学, 総合生活学科, 講師 (80360262)
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| Project Period (FY) |
2009 – 2011
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| Keywords | カプサイシン / ジンゲロール / 腎血管性高血圧 / 血管弛緩反応 / 血管肥厚 / 高血圧発症予防 |
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| Research Abstract |
In our previous study, we observed that acute bolus injections of low-dose capsaicin and gingerol decreased blood pressure(BP) with vasodilation via vanilloid receptor-stimulation. In this study, we observed the chronic effects of dietary intake of capsaicin and ginger extract, which contains much gingerol, on BP and aortic morphology and function in renovascular hypertensive model rats. Each diet alleviated the BP elevation, as well as aortic media thickness and the decrements in aortic vasodilation, in the hypertensive model rats, suggesting that dietary intake of capsaicin and ginger extract containing gingerol may have a preventive effect on the onset and development of this kind of hypertension.
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