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2011 Fiscal Year Final Research Report

Screening and Identification of anti-mycobacterial compounds from polyphenols.

Research Project

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Project/Area Number 21500806
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Eating habits, studies on eating habits
Research InstitutionSonoda Women's University

Principal Investigator

OZEKI Yuriko  園田学園女子大学, 健康科学部, 教授 (00169301)

Co-Investigator(Kenkyū-buntansha) NIKI Mamiko (YOSIMURA Mamiko)  大阪市立大学, 大学院・医学研究科, 助教 (20438229)
TAMARU Aki  大阪府立公衆衛生研究所, 感染症部, 主任研究員 (70270767)
Project Period (FY) 2009 – 2011
Keywords結核 / ポリフェノール / 免疫
Research Abstract

We carried out screening of anti-mycobacterial compounds from polyphenols. Some polyphenols suppressed proliferation of Mycobacterium tuberculosis growing in macrophages at lower concentrations than those suppressed in 7H9 culture medium. These facts indicate that these polyphenols possess bacteriostatic effects against M. tuberculosis via activation of host immunity. These data suggest use of the polyphenols for prevention and treatment of tuberculosis.

  • Research Products

    (37 results)

All 2012 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (20 results) Book (1 results)

  • [Journal Article] A novel mechanism of growth phase-dependent tolerance to isoniazid in mycobacteria2012

    • Author(s)
      Niki, M., Niki, M., Tateishi Y., Ozeki Y., Kirikae T, Lewin A., Inoue Y, Matsumoto M., Dahl JL., Ogura H., Kobayashi K., and Matsumoto S.
    • Journal Title

      J Biol Chem in press

    • Peer Reviewed
  • [Journal Article] 新しい結核ワクチ開発の展望2012

    • Author(s)
      松本壮吉、尾関百合子、小林和夫
    • Journal Title

      臨床と微生物

      Volume: Vol39、2号 Pages: 131-136

  • [Journal Article] Loss of anti-mycobacterial efficacy in mice over time following vaccination with Mycobacterium bovis bacillus Calmette-Guerin2011

    • Author(s)
      Ozeki, Y., Y. Hirayama, T. Takii, S. Yamamoto, K. Kobayashi, and S. Matsumoto
    • Journal Title

      Vaccine

      Volume: 29 Pages: 6881-6887

    • Peer Reviewed
  • [Journal Article] A histone-like protein of mycobacteria possesses ferritin superfamily protein-like activity and protects against DNA damage by Fenton reaction2011

    • Author(s)
      Takatsuka M, Osada-Oka M, Satoh EF, Kitadokoro K, Nishiuchi Y, Niki M, et al.
    • Journal Title

      PLoS One

      Volume: 6 Pages: 20985

    • Peer Reviewed
  • [Journal Article] Structure and Hos t Recogn i t i o n o f S e r o t ype 1 3 Glycopeptidolipid from Mycobacterium intracellulare2011

    • Author(s)
      Naka T, Nakata N, Maeda S, Yamamoto R, Doe M, Mizuno S, Niki M, et al.
    • Journal Title

      J Bacteriol

      Volume: 93 Pages: 5766-5774

    • Peer Reviewed
  • [Journal Article] Effects of non-iron metalloporphyrins on growth and gene expression of Porphyromonas gingivalis2011

    • Author(s)
      Yukitake H., M. Naito, K. Sato, M. Shoji, N. Ohara, M. Yoshimura, et al.
    • Journal Title

      Microb Immun

      Volume: 55 Pages: 141-153

    • Peer Reviewed
  • [Journal Article] The Lipid Phenotype of two Distinct Subpopulations of Mycobacterium bovis Bacillus Calmette-Guerin Tokyo 172 Substrain2011

    • Author(s)
      Naka T, Maeda S, Niki M, Ohara N, Yamamoto S, Yano I, Maeyama J, et al.
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 44153-44161

    • Peer Reviewed
  • [Journal Article] Changes in salivary antimicrobial peptide, immunoglobulin A and cortisol after prolonged strenuous exercise2011

    • Author(s)
      Usui T., T. Yoshikawa, K. Orita, SY. Ueda, Y. Katsura, S. Fijimoto, and M. Yoshimura
    • Journal Title

      Eur J Appl Physiol

      Volume: 111 Pages: 2005-2014

    • Peer Reviewed
  • [Journal Article] 結核研究の新たな展開-潜在性結核と結核菌:休眠現象の分子メカニズム2011

    • Author(s)
      仁木満美子、仁木誠、尾関百合子、岡真優子、松本壮吉
    • Journal Title

      最新医学

      Volume: Vol66、3号 Pages: 149-155

  • [Journal Article] Transient role of CD4+ CD25+ regulatory T cells in mycobacterial infection in mice2010

    • Author(s)
      Ozeki, Y., I. Sugawara, T. Udagawa, T. Aoki, M. Osada-Oka, Y. Tateishi, H. Hisaeda, Y. Nishiuchi, N. Harada, K. Kobayashi, and S. Matsumoto
    • Journal Title

      Int Immunol

      Volume: 22 Pages: 179-189

    • Peer Reviewed
  • [Journal Article] Tetratricopeptide repeat proteinassociatedproteins contribute to the virulence of Porphyromonas gingivalis2010

    • Author(s)
      Kondo Y., N. Ohara, K. Sato, M. Yoshimura, et al.
    • Journal Title

      Infect Immun

      Volume: 78 Pages: 2846-2856

    • Peer Reviewed
  • [Journal Article] Identification of Mycobacterium tuberculosis clinical isolates in Bangladesh by a species distinguishable multiplex PCR2010

    • Author(s)
      Nakajima C, Rahim Z, Fukushima Y, SugawaraI, Zanden A G, Tamaru A, Suzuki Y.
    • Journal Title

      BMC Infect Dis

      Volume: 10 Pages: 118-124

    • Peer Reviewed
  • [Journal Article] A novel method for the purification of DNA by capturing nucleic acid and magnesium complexes on non-woven fabric filters under alkaline conditions for the gene diagnos is of tuberculosis by loop-mediated Isothermal amplification(LAMP)2010

    • Author(s)
      Fukasawa T, Oda N, Wada Y, Tamaru A, Fukushima Y, Nakajima C, Suzuki Y.
    • Journal Title

      Jpn J Infect Dis

      Volume: 63 Pages: 246-25

    • Peer Reviewed
  • [Journal Article] Mycobacteria Exploit Host Hyaluronan for Efficient Extracellular Replication2009

    • Author(s)
      Hirayama, Y., M. Yoshimura, Y. Ozeki, I. Sugawara, T. Udagawa, S. Mizuno, N. Itano, K. Kimata, A. Tamaru, H. Ogura, K. Kobayashi, and S. Matsumoto
    • Journal Title

      PLoS Pathog

      Volume: 5 Pages: 1000643

    • Peer Reviewed
  • [Journal Article] Virulence of Mycobacterium avium complex strains isolated from immune-competent patients2009

    • Author(s)
      Tateishi, Y., Y. Hirayama, Y. Ozeki, Y. Nishiuchi, M. Yoshimura, J. Kang, A. Shibata, K. Hirata, K. Kitada, S. Kitada, R. Maekura, H. Ogura, K. Kobayashi, and S. Matsumoto
    • Journal Title

      Microb Pathog

      Volume: 46 Pages: 6-12

    • Peer Reviewed
  • [Journal Article] Mycobacterium avium complex organisms predominantly colonize in the bathtub inlets of patients bathrooms2009

    • Author(s)
      Nishiuchi, Y., A. Tamura, S. Kitada, T. Taguri, S. Matsumoto, Y. Tateishi, M. Yoshimura, Y. Ozeki, N. Matsumura, H. Ogura, and R. Maekura
    • Journal Title

      Jpn J Infect Dis

      Volume: 62 Pages: 182-186

    • Peer Reviewed
  • [Presentation] マウスモデルにおけるBCGワクチン効果の減衰に関する研究2012

    • Author(s)
      尾関百合子、平山幸雄、岡真優子、立石善隆、瀧井猛将, 他
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      20120327-29
  • [Presentation] 休眠時における抗酸菌の遺伝子発現解析2012

    • Author(s)
      仁木満美子、仁木誠、小林和夫
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      20120327-29
  • [Presentation] マクロファージのグルコース代謝と宿主内結核菌の増殖2012

    • Author(s)
      岡真優子、合田亘人、曽我朋義、尾関百合子、小林和夫、松本壮吉、岩尾洋
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      20120327-29
  • [Presentation] ケニアの学生における、結核菌タンパク質に対する免疫応答の分析2012

    • Author(s)
      井上学、岡真優子、仁木満美子、尾関百合子、一瀬休生、小林和夫、松本壮吉
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      20120327-29
  • [Presentation] 高病原性Mycobacterium intracellulare臨床分離株のドラフトゲノム解析2012

    • Author(s)
      立石義隆、小倉義俊、平山幸雄、尾関百合子、西内由紀子, ほか
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      20120327-29
  • [Presentation] Mycobacterium DNA-binding protein 1(MDP1)に見出されたFerritin-super family蛋白質様活性2012

    • Author(s)
      松本壮吉、岡真優子、西内由紀子、仁木満美子、尾関百合子, 他
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Year and Date
      20120327-29
  • [Presentation] Loss of anti-mycrobial effica cy in mice over time following vaccinati on with Mycobacterium bovis bacillus Calmette-Guerin2011

    • Author(s)
      Y. Ozeki, Y. Hirayama, T. Takii, S. Yamamoto, et al.
    • Organizer
      International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      20110909-10
  • [Presentation] 患者年齢構成の異なる地域間での結核菌地域分子疫学比較2011

    • Author(s)
      田丸亜貴、和田崇之、岩本朋忠、吉田志緒美、野尻孝子
    • Organizer
      第86回日本結核病学会総会
    • Place of Presentation
      東京
    • Year and Date
      20110602-03
  • [Presentation] Loss of anti-mycobacterial efficacy in mice over t i m e f o l l o w i n g v a c c i n a t i o n w i t h Mycobacterium bobis bacillus Calmette-Gerin2011

    • Author(s)
      Ozeki, Y., Hirayama, Y., Osada-Oka M., Takii, T., Yamamoto S., et al.
    • Organizer
      第64回日本細菌学会関西支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-11-19
  • [Presentation] Transient role of CD4+ CD25+ regulatory T cells in Mycobacterium tuberculosis infection in mice2010

    • Author(s)
      Y. Ozeki, I. Sugawara, T. Udagawa, H. Hisaeda, K. Kobayashi, and S. Matsumoto
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe, Japan, August
    • Year and Date
      20100822-27
  • [Presentation] Transient role of CD4+ CD25+ regulatory T cells in Mycobacterium tuberculosis infection in mice2010

    • Author(s)
      Y. Ozeki, I. Sugawara, T. Udagawa, T. Aoki, M. Osada-Oka, Y. Tateishi, et al
    • Organizer
      45th US-Japan, Cooperative Medical Science Program
    • Place of Presentation
      Cambridge, USA
    • Year and Date
      20100713-17
  • [Presentation] 大阪府における多発性広域感染株について2010

    • Author(s)
      田丸亜貴、和田崇之、長谷篤、岩本朋忠、吉田志緒美、前田伸司、松本智成
    • Organizer
      第85回日本結核病学会総会
    • Place of Presentation
      京都
    • Year and Date
      20100520-21
  • [Presentation] 結核菌感染における制御性T細胞の関与2010

    • Author(s)
      尾関百合子、菅原勇、岡真優子、小林和夫、松本壮吉
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      20100327-29
  • [Presentation] A ferritin superfamily-like protein in mycobacteria2009

    • Author(s)
      Mayuko Osada-Oka, Masaki Takatsuka, F Eisuke Sato, Yuriko Ozeki, Mamiko Yoshimura, Masayasu Inoue, Kazuo Kobayashi, Sohkichi Matsumoto
    • Organizer
      THE9TH AWAJI INTERNATIONAL FORUM
    • Place of Presentation
      淡路島
    • Year and Date
      20090908-11
  • [Presentation] 結核菌の増殖に対するヒアルロン酸の作用2009

    • Author(s)
      平山幸雄、吉村満美子、尾関百合子、菅原勇、小林和夫、松本壮吉
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20090312-14
  • [Presentation] 急速な臨床経過に合致した高病原性Mycobacterium avium-intracellulare complex菌株の同定2009

    • Author(s)
      立石善隆、平山幸雄、尾関百合子、西内由紀子、吉村満美子、小林和夫、松本壮吉
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20090312-14
  • [Presentation] 抗結核菌薬スクリーニング系の確立と実践2009

    • Author(s)
      尾関百合子、原田誠、西内由紀子、山本三郎、小林和夫、松本壮吉
    • Organizer
      第82回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      20090312-14
  • [Presentation] 結核菌感染における制御性T細胞の役割2009

    • Author(s)
      尾関百合子、菅原勇、小林和夫、松本壮吉
    • Organizer
      第62回日本細菌学会関西支部会
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-14
  • [Presentation] 抗酸菌は宿主ヒアルロン酸を利用して細胞外増殖を行う2009

    • Author(s)
      平山幸雄、吉村満美子、尾関百合子、田丸亜貴、小倉壽、小林和夫、松本壮吉
    • Organizer
      第62回日本細菌学会関西支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-11-14
  • [Presentation] 大阪における多剤耐性・超多剤耐性結核の疫学とその制圧に関する研究2009

    • Author(s)
      田丸亜貴、尾関百合子
    • Organizer
      第42回関西抗酸菌研究会
    • Place of Presentation
      大阪
    • Year and Date
      2009-06-26
  • [Book] BCG-Vaccine and Adjuvant2012

    • Author(s)
      Takii T, Maeyama J, Yamamoto S, Niki M, et al.
    • Total Pages
      272
    • Publisher
      JATA(公益財団法人結核予防会)

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Published: 2013-07-31  

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