2011 Fiscal Year Final Research Report
Analysis of the bioactive substances contained in the lactic acid bacteria-metabolic products from soybean milk
| Project/Area Number |
21500810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Nagasaki International University |
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Principal Investigator |
SAKAKIBARA Ryuzo 長崎国際大学, 薬学部・生化学研究室, 教授 (30127229)
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| Co-Investigator(Kenkyū-buntansha) |
FUKASAWA Masashi 長崎国際大学, 薬学部・生化学研究室, 准教授 (20238439)
NODAKE Yuich 長崎国際大学, 薬学部・生化学研究室, 助教 (30332282)
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| Project Period (FY) |
2009 – 2011
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| Keywords | バイオジェニックス / 乳酸菌 / 生理活性 / ガン / 発酵 / 肝炎 / 食品 |
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| Research Abstract |
PS-B1 is fermented products cultivated from soybean milk using lactic acid bacteria. We found that PS-B1 inhibited significantly the growth of human leukemia HL-60 cells by the induction of apoptosis and the increase of the intracellular reactive oxygen species was important for apoptosis. In the experiments using the alcoholic injury liver model constructed by using rat hepatocytes and hepatic stellate cells, PS-B1 inhibited the necrosis of hepatocytes and suppressed the production of the collagen in hepatic stellate cells. PS-B1 also indicated the liver preservation action against the viral and drug-induced injury liver model.
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[Patent(Industrial Property Rights)] 新規乳酸菌とそれを用いた肝細胞保護剤(保護成分)
Inventor(s)
榊原隆三,野嶽勇一,深澤昌史,河村俊哉,晦日房和,玉屋圭,松本周三
Industrial Property Rights Holder
榊原隆三,野嶽勇一,深澤昌史,河村俊哉,晦日房和,玉屋圭,松本周三
Industrial Property Number
特許
