Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status

2011 Fiscal Year Final Research Report

• Project/Area Number: 21500816
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: USUI Takeshi 独立行政法人国立病院機構(京都医療センター臨床研究センター), 内分泌代謝高血圧研究部, 研究室長(臨床内分泌代謝) (20271512)
• Project Period (FY): 2009 – 2011
• Keywords: イソフラボン / エクオール肥満 / 代謝症候群

Research Abstract

The ratio of equol non-producers in overweight or obese populations might be higher than generally reported. Natural S-equol might have a role in glycemic control and in the prevention of cardiovascular disease by its effects to lower LDL-C levels and CAVI scores in overweight or obese individuals.

Research Products

• [Journal Article] Two rare TSH receptor amino acid substitutions in toxic thyroid adenomas (2012)
  • Author(s): Nanba K, Usui T, Minamiguchi S, Mori Y, Watanabe Y, Honda K, Asato R, Nakao K, Kawashima ST, Yuno A, Tamanaha T, Tagami T, Naruse M, Akiyama Y, Shimatsu A
  • Journal Title: Endocrine journal Volume: 59 Pages: 13-19
• [Journal Article] Confirmatory Testing in Primary Aldosteronism (2012)
  • Author(s): Nanba K, Tamanaha T, Nakao K, Kawashima ST, Usui T, Tagami T, Okuno H, Shimatsu A, Suzuki T, Naruse M
  • Journal Title: J Clin Endocrinol Metab
• [Journal Article] Salivary cortisol levels are associated with outcomes of weight reduction therapy in obese Japanese patients (2012)
  • Author(s): Himeno A, Satoh-Asahara N, Usui T, Wada H, Tochiya M, Kono S, Yamada-Goto N, Katsuura G, Hasegawa K, Nakao K, Shimatsu A
  • Journal Title: Metabolism Volume: 61 Pages: 255-261
• [Journal Article] Effects of natural S-equol supplements on overweight or obesity and metabolic syndrome in the Japanese, based on sex and equol status (2011)
  • Author(s): Usui T, Tochiya M, Sasaki Y, Muranaka K, Yamakage H, Himeno A, Shimatsu A, Inaguma A, Ueno T, Uchiyama S, Satoh-Asahara N
  • Journal Title: Clinical endocrinology
  • DOI: doi:10.1111/j.1365-2265.2012.04400.x.
• [Journal Article] Inheritance of an autosomal recessive disorder, Gitelman's syndrome, across two generations in one family (2011)
  • Author(s): Yagi H, Yahata K, Usui T, Hasegawa C, Seta K, Sugawara A
  • Journal Title: Intern Med Volume: 50 Pages: 1211-1214
• [Journal Article] Aberrant expression of thyroid hormone receptor beta isoform may cause inappropriate secretion of TSH in a TSH-secreting pituitary adenoma (2011)
  • Author(s): Tagami T, Usui T, Shimatsu A, Beniko M, Yamamoto H, Moriyama K, Naruse M
  • Journal Title: J Clin Endocrinol Metab Volume: 96 Pages: 948-952
• [Journal Article] Prevention of type 2 diabetes in a primary healthcare setting : three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance (2011)
  • Author(s): Sakane N, Sato J, Tsushita K, Tsujii S, Kotani K, Tsuzaki K, Tominaga M, Kawazu S, Sato Y, Usui T, Kamae I, Yoshida T, Kiyohara Y, Sato S, Kuzuya H
  • Journal Title: BMC Public Health Volume: 11 Pages: 40
• [Journal Article] Successful treatment of Cushing's disease caused by ectopic intracavernous microadenoma (2011)
  • Author(s): Koizumi M, Usui T, Yamada S, Fujisawa I, Tsuru T, Nanba K, Hagiwara H, Kimura T, Tamanaha T, Tagami T, Naruse M, Shimatsu A
  • Journal Title: Pituitary Volume: 14 Pages: 295-298
• [Presentation] The effect of natural S-equol supplement on metabolic parameters in overwight adult Japanese males and females in equol producers and non-producers (2012)
  • Author(s): Takeshi Usui, Mayu Tochiya, Noriko Satoh-Asahara, Belinda H Jenks, Tomoni Ueno, Shigeto Uchiyama, Akirta Shimats
  • Organizer: Women's Health 2012
  • Place of Presentation: ワシントンDC
  • Year and Date: 2012-03-16
• [Presentation] The effect of equol on obesity and metabolic syndrome in Japanese, from the standpoint of gender and equol producing capability (2010)
  • Author(s): Takeshi Usui, Noriko Satho-Asahara, Asami Inaguma, Tomomi Ueno, Shigeto Uchiyama
  • Organizer: 9^<th> International Symposium on the Role of Soy in Health Promotion and Chronic Disease Prevention and Treatment
  • Place of Presentation: Washington DC
  • Year and Date: 20101016-19
• [Presentation] The effect of equol on obesity and metabolic syndrome in Japanese, from the standpoint of gender and equol producing capability (2010)
  • Author(s): Shigeto Uchiyama, Tomomi Ueno, Asami Inaguma, Noriko Satoh-Asahara, Takeshi Usui
  • Organizer: North American Menopause Socciety
  • Place of Presentation: Chicago
  • Year and Date: 20101006-09
• [Presentation] 肥満症における大豆イソフラボン代謝物・エクオールの産生能とエクオール投与の効果 (2010)
  • Author(s): 橡谷真由、浅原哲子、臼井健, 他3名
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 栃木
  • Year and Date: 20101001-02