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2011 Fiscal Year Final Research Report

Studies on age-dependency of radiation-induced mutation and its mechanism

Research Project

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Project/Area Number 21510053
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTohoku University

Principal Investigator

UEHARA Yoshihiko  東北大学, 大学院・医学系研究科, 助教 (30223499)

Co-Investigator(Kenkyū-buntansha) ONO Tetsuya  東北大学, 大学院・医学系研究科, 教授 (00107509)
Project Period (FY) 2009 – 2011
Keywords放射線 / マウス / 被曝時年齢依存性 / 突然変異 / DNA修復
Research Abstract

Although it is well established that radiation-induced cancer shows age-dependency at which the individuals are exposed, the mechanism responsible for it is not understood. We hypothesized that the age-dependency could be explained by a difference in the efficiency of mutation induction with radiation. Using lacZ-transgenic mice, we studied dose responses of mutation induction in liver at different ages. The efficiency changed with age but the mode of the change was different from that of cancer induction. Thus, mutation induction could not explain the age-dependency of cancer induction.

  • Research Products

    (1 results)

All 2011

All Presentation (1 results)

  • [Presentation] 放射線誘発突然変異のエイジ依存性2011

    • Author(s)
      小野哲也、上原芳彦、池畑広伸、小村潤一郎
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-11-18

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Published: 2013-07-31   Modified: 2014-11-19  

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