2011 Fiscal Year Final Research Report
Studies on age-dependency of radiation-induced mutation and its mechanism
| Project/Area Number |
21510053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ONO Tetsuya 東北大学, 大学院・医学系研究科, 教授 (00107509)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 放射線 / マウス / 被曝時年齢依存性 / 突然変異 / DNA修復 |
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| Research Abstract |
Although it is well established that radiation-induced cancer shows age-dependency at which the individuals are exposed, the mechanism responsible for it is not understood. We hypothesized that the age-dependency could be explained by a difference in the efficiency of mutation induction with radiation. Using lacZ-transgenic mice, we studied dose responses of mutation induction in liver at different ages. The efficiency changed with age but the mode of the change was different from that of cancer induction. Thus, mutation induction could not explain the age-dependency of cancer induction.
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