2011 Fiscal Year Final Research Report
Identification and characterization of biological functions of DNA repair enzymes that recognize oxidative base damage
| Project/Area Number |
21510056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
AKIYAMA Qiu-mei (ZHANG Qiu-mei) 京都大学, 大学院・理学研究科, 准教授 (00260604)
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| Co-Investigator(Kenkyū-buntansha) |
HASHIGUCHI Kazunari 京都大学, 大学院・理学研究科, 助教 (80400414)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 放射線 / 活性酸素 / 塩基損傷 / DNA修復 / 突然変異 |
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| Research Abstract |
We first identified three kinds of base excision repair enzymes(Nth, APN-1 and EXO-3), pyrophosphatases for oxidized deoxyribonucleotides(NDX-1, NDX-2 and NDX-4), mismatch repair enzymes(MSH2, MSH6, MLH1 and PMS2) and OXR1 protein in the nematode C. elegans. Furthermore, the present study revealed critical roles of these proteins in prevention against oxidative stress using deficient mutant or RNAi knockdown worms. In addition, we also identified some DNA repair enzymes in the ascidian Ciona intestinalis.
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[Journal Article] Mitochondria-targeted super oxide dismutase(SOD2) regulates radiation resistance and radiation stress response in HeLa cells.2012
Author(s)
Hosoki, A., S. Yonekura, Q-L. Zhao, Z-L. Wei, I. Takasaki, Y. Tabuchi, L-L. Wang, S. Hasuike, T. Nomura, A. Tachibana, K. Hashiguchi, S. Yonei, T. Kondo and Q-M. Zhang-Akiyama
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Journal Title
J. Radiat. Res.
Volume: 53
Pages: 58-71
DOI
Peer Reviewed
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