2011 Fiscal Year Final Research Report
Molecular mechanisms for radioadaptive responses
| Project/Area Number |
21510060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
NENOI Mitsuru 独立行政法人放射線医学総合研究所, 放射線防護研究センター, プログラムリーダー (10164659)
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| Co-Investigator(Kenkyū-buntansha) |
WANG Bing 独立行政法人放射線医学総合研究所, 放射線防護研究センター, チームリーダー (10300914)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 応答 / 放射線適応応答 |
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| Research Abstract |
The radioadaptive response is defined as a biological response by which cells or animals acquire resistance against subsequent high dose radiation. In this research, we showed that the radioadaptive response of human lymphoblastoid cells in terms of radiation-induced mutation was associated with activation of a DNA repair system with high fidelity, and that the response was not primarily related to regulation of the cell cycle or apoptosis. In addition, we showed that the radioadaptive response of fetal mice in terms of radiation-induced prenatal death and teratogenesis was functionally associated with Tead3, Csf1 and Cacna1a genes.
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