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2011 Fiscal Year Final Research Report

Basic study on the effect of endocrine disruptors on reptiles reproduction using a model of American alligators, Alligator Mississippiensis

Research Project

  • PDF
Project/Area Number 21510068
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Risk sciences of radiation/Chemicals
Research InstitutionTottori University

Principal Investigator

OHTA Yasuhiko  鳥取大学, 農学部・獣医学科, 教授 (60069078)

Co-Investigator(Kenkyū-buntansha) KATSU Yoshinao  北海道大学, 大学院・理学研究院, 准教授 (00332180)
Co-Investigator(Renkei-kenkyūsha) TAKEUCHI Takashi  鳥取大学, 農学部・獣医学科, 准教授 (10325061)
IGUCHI Taisen  大学共同利用機関法人自然科学研究機構, 岡崎統合バイオサイエンスセンター, 教授 (90128588)
Project Period (FY) 2009 – 2011
Keywords環境ホルモン / ハ虫類 / アメリカンアリゲーター / 性分化 / 生殖輸管
Research Abstract

In American alligator showing temperature-dependent sex determination(TSD), development of reproductive organs, ontogeny of expression of estrogen and progesteronereceptor and candidates involved in the TSD were identified during the thermo-sensitiveperiod. These results may contribute to the understanding of endocrine disrupters onreptiles.

  • Research Products

    (9 results)

All 2011 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Altered gonadal expression of TGFαsuperfamily signaling factors in environmental contaminant-exposed juvenile alligators2011

    • Author(s)
      Moore, B. C., Milnes, M. R., Kohno, S., Katsu, Y., Iguchi, T., Woodruff, T. K., Guillette, L, Jr.
    • Journal Title

      J. Steroid Biochem. Mol. Biol.

      Volume: 127 Pages: 58-63

    • DOI

      DOI:10.1016/j.jsbmb.2011.01.004

    • Peer Reviewed
  • [Journal Article] Sex steroid and thyroid hormone receptor expressions in the thyroid of the American alligator(Alligator mississippiensis) during different life stages2011

    • Author(s)
      Bermudez, D., Skotko, J. P., Ohta, Y. Boggs, S. S. P., Iguchi, T., Guillette, L. J, Jr.
    • Journal Title

      J. Morphology

      Volume: 271 Pages: 698-703

    • DOI

      DOI:10.1002/jmor.10936

    • Peer Reviewed
  • [Journal Article] Molecularcloning pf anti-Mullerian hormone from the American alligator, Alligator mississippiensi2011

    • Author(s)
      Urushitani, H., katsu, Y., Miyagawa, S., Kohno, S., Ohta, Y., Guillette, L. J. Jr., Iguchi, T.
    • Journal Title

      Mol. Cel. Endcrinol.

      Volume: 333 Pages: 190-199

    • DOI

      DOI:10.1016/j.mce.2010.12.025

    • Peer Reviewed
  • [Journal Article] Molecular cloning characterization, and chromosome mapping of reptilian estrogen receptors2010

    • Author(s)
      Katsu, Y., Matsubara, K., Kohno, S., Toriba, M., Oka, K., Guillette, L. J, Jr., Ohta, Y., Iguchi, T.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 5710-5720

    • DOI

      DOI:10.1210/en.2010-0356

    • Peer Reviewed
  • [Journal Article] Potential Contributions of Heat Shock Proteins to Temperature-Dependent Sex Determination in the American Alligator2010

    • Author(s)
      Kohno, S., Katsu, Y., Urushitani, U., Ohta, Y., Iguchi, T., Guillette, L. Jr.
    • Journal Title

      Sexual Devel.

      Volume: 4 Pages: 73-87

    • DOI

      DOI:10.1159/000260374

    • Peer Reviewed
  • [Presentation] アメリカンアリゲーターのコルチコイド受容体の単離と機能解析2011

    • Author(s)
      岡香織・太田康彦・井口泰泉・勝義直
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      旭川市大雪クリスタルホール(旭川市)
    • Year and Date
      2011-09-11
  • [Presentation] Which estrogen receptor(ESR1 ; ERαor EXR2 ; ERβ) is involved in sex determination and gonadal differentiation? Michigan University2011

    • Author(s)
      Kohno, S. Katus, Y. Ohta, Y. Igutchi, T., Guillette, L. J.
    • Organizer
      NASCE2011
    • Place of Presentation
      Michigan league(Ann Arbor)
    • Year and Date
      2011-07-14
  • [Presentation] A Preliminary Study on Immunohisitochemical Detection of Estrogen Receptor in American Alligator Oviducts-Specificity of Antibodies2009

    • Author(s)
      Ohta, Y., Urushidani, H., Takeuchi, T., Iguchi, T., Katsu, Y., Kohno, S., Brandon, M. and Guillette, L. J.
    • Place of Presentation
      Tulene University(New Orleans)
    • Year and Date
      2009-10-21
  • [Remarks]

    • URL

      http://staff.muses.tottori-u.ac.jp/ohta

URL: 

Published: 2013-07-31  

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