2011 Fiscal Year Final Research Report
Effect of combined exposures to multiple chemicals and ultraviolet rays on recent increase of skin cancer-from a view point of histone modifications
| Project/Area Number |
21510071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | University of Shizuoka |
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Principal Investigator |
IBUKI Yuko 静岡県立大学, 環境科学研究所, 准教授 (30236781)
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| Co-Investigator(Kenkyū-buntansha) |
TOYOOKA Tatsushi 静岡県立大学, 環境科学研究所, 助教 (40423842)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ヒストン / リン酸化 / アセチル化 / 複合影響 / エピジェネティクス / 紫外線 / DNA損傷 |
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| Research Abstract |
Histone proteins have become a focus of research in many fields because their modifications have an important role in gene expression and cancer. In this study, we examined the influence of several chemicals on histone modifications. Side-stream smoke, formaldehyde, etc. changed the modifications of some histones(phosphorylation of histone H3(S10), acetylation of histone H3(K9, K14) and phosphorylation of histone H2AX(S139)). Phosphorylation of histone H3(S10) related with induction of proto-oncogenes, c-fos and c-jun. In the conditions of remarkable histone modifications, UVB-induced cell death was enhanced. These results suggested that histone modifications by several chemicals might change the sensitivity to DNA damaging agents, indicating the contribution of histone modifications to increase of skin cancer.
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